Background

Tissue replacement is among the most important challenges in biotechnology worldwide.

Scope of review

We aim to highlight the importance of the intricate feedback between rheological properties and materials science and cell biological parameters in order to obtain an efficient bioink design, supported by various practical examples.

Major conclusions

Viscoelastic properties of bioink formulas, rheological properties, injection speed and printing nozzle diameter must be considered in bioink design. These properties are related to cell behavior and the survival rate during and after printing. Mechanosensing can strongly influence epigenetics to modify the final cell phenotype, which can affect the replacement tissue.

General significance

In tissue engineering, biotechnologists must consider the biophysical properties and biological conditions of the materials used, as well as the material delivery mode (in a case or tissue) and maturation mode (curing or biomass), to ensure the development off appropriate materials mimicking the native tissue.

中文翻译：

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量身定制生物墨水的流变特性，以改善用于组织更换的生物印刷和生物组装

背景

组织替代是全球生物技术中最重要的挑战之一。

审查范围

我们的目的是强调流变性质与材料科学以及细胞生物学参数之间复杂反馈的重要性，以便获得有效的生物墨水设计，并得到各种实例的支持。

主要结论

在生物墨水设计中必须考虑生物墨水配方的粘弹性，流变性，注射速度和印刷喷嘴直径。这些特性与打印过程中和打印后的细胞行为和存活率有关。机械传感可以强烈影响表观遗传学，以修饰最终的细胞表型，从而影响替代组织。

一般意义

在组织工程中，生物技术人员必须考虑所用材料的生物物理特性和生物学条件，以及材料的输送方式（在某种情况下还是在组织中）和成熟方式（固化或生物质），以确保开发出可模仿材料的合适材料。天然组织。