Asymmetric Total Synthesis of (+)-21- epi -Eburnamonine Via a Photocatalytic Radical Cascade Reaction,Natural Products and Bioprospecting

当前位置： X-MOL 学术 › Nat. Prod. Bioprospect. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Asymmetric Total Synthesis of (+)-21- epi -Eburnamonine Via a Photocatalytic Radical Cascade Reaction
Natural Products and Bioprospecting ( IF 4.8 ) Pub Date : 2020-11-05 , DOI: 10.1007/s13659-020-00276-8
Yuan Huang , Fanglin Xue , Hengmao Liu , Fei Xue , Xiao-Yu Liu , Hao Song , Yong Qin

An asymmetric total synthesis of (+)-21-epi-eburnamonine has been achieved. Key features of the synthesis include a visible-light photocatalytic intra-/intramolecular radical cascade reaction to assemble the tetracyclic ABCD ring system, and a highly diastereoselective Johnson-Claisen rearrangement to establish the C20 all-carbon quaternary stereocenter.