One class of molecules that are now coming to be recognized as essential for our understanding of the nervous system are the lysophospholipids. One of the major signaling lysophospholipids is lysophosphatidic acid, also known as LPA. LPA activates a variety of G protein-coupled receptors (GPCRs) leading to a multitude of physiological responses. In this review, I describe our current understanding of the role of LPA and LPA receptor signaling in the development and function of the nervous system, especially the central nervous system (CNS). In addition, I highlight how aberrant LPA receptor signaling may underlie neuropathological conditions, with important clinical application.

现在被认为对我们理解神经系统必不可少的一类分子是溶血磷脂。溶血磷脂的主要信号之一是溶血磷脂酸，也称为 LPA。LPA 激活多种 G 蛋白偶联受体 (GPCR)，导致多种生理反应。在这篇综述中，我描述了我们目前对 LPA 和 LPA 受体信号在神经系统，尤其是中枢神经系统 (CNS) 的发育和功能中的作用的理解。此外，我强调了异常 LPA 受体信号可能是神经病理学疾病的基础，并具有重要的临床应用。