The ¹⁹F nuclear magnetic resonance (NMR) has been widely employed as a detection tool in biological studies due to its low biological background, noninvasiveness, high sensitivity, and real-time monitoring capability. Herein, we report a one-pot synthesis of halloysite nanotubes (HNTs) treated with benzeneboronic acids (6FBB) to afford the HNT-based ¹⁹F NMR probe which is capable to detect the H₂O₂ in low concentration. The product was well characterized by nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR), transmission electron microscope (TEM), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD). The intensity of signals of ¹⁹F was enhanced with the increasing concentration of fluorine, and the signals apparently shifted from − 62.68 to − 62.85 ppm upon the addition of H₂O₂. The obtained ¹⁹F NMR probes also displayed a long spin-spin (T2) relaxation time (91.27 ms), which can strengthen image intensity. Moreover, the ¹⁹F NMR probe exhibited non-toxic against HeLa cell. The ¹⁹F NMR probe may serve as a desirable candidate to predict the change of H₂O₂ in vivo.

在¹⁹ ˚F核磁共振（NMR）已被广泛用作生物研究的检测工具，由于其低生物背景，无创性，高灵敏度，和实时监控能力。在本文中，我们报告了用苯硼酸（6FBB）处理的一锅法合成埃洛石纳米管（HNT），以提供基于HNT的¹⁹ F NMR探针，该探针能够检测低浓度的H ₂ O ₂。该产品通过核磁共振（NMR），傅立叶变换红外光谱（FTIR），透射电子显微镜（TEM），X射线光电子能谱（XPS）和X射线衍射（XRD）进行了很好的表征。¹⁹的信号强度F随着氟浓度的增加而增强，添加H ₂ O _2后，信号明显从-62.68 ppm移至-62.85 ppm 。获得的¹⁹ F NMR探针还显示出长的自旋自旋（T2）弛豫时间（91.27 ms），这可以增强图像强度。此外，¹⁹ F NMR探针对HeLa细胞无毒。的¹⁹ F NMR探针可以用作理想的候选预测H的变化₂ Ó ₂体内。