Co-occurrence of bacteria and algae can be traced back to billions of years ago. Their coexistence for more than 200 million years in common habitat has fostered a multitude of promising interactions among these two groups over evolutionary time scales. These associated bacteria produce various biologically active secondary metabolites and play a pivotal role in algal growth and metabolism. Consequently, specific chemical microenvironment created by algal microbiome signifies a promising source of bioactive compounds. Although these associations may be of substantial importance, only limited knowledge on the chemical ecology of algal microhabitat is available. Thus, better insight into the metabolic capabilities of phycosphere microbiome could allow targeted isolation of novel bioactive compounds with manifold beneficial effects. Moreover, further research contributing towards the chemistry behind these interactions is needed for exploring phycosphere bacteria for desired industrial and biotechnological applications.

细菌和藻类的同时存在可以追溯到数十亿年前。它们在共同栖息地中共存超过2亿年，在进化的时间尺度上促进了这两个群体之间的许多有希望的相互作用。这些相关细菌产生各种具有生物活性的次生代谢产物，并在藻类生长和代谢中起关键作用。因此，藻类微生物组产生的特定化学微环境标志着有希望的生物活性化合物来源。尽管这些关联可能非常重要，但对于藻类微生境的化学生态学只有有限的知识。因此，更好地了解藻圈微生物组的代谢能力可以实现目标分离具有多种有益作用的新型生物活性化合物。此外，