HAX1 is a multifunctional protein involved in many cellular processes, including apoptosis, cell migration and calcium homeostasis, but its mode of action still remains obscure. Multiple HAX1 protein partners have been identified, but they are involved in many distinct pathways, form different complexes and do not constitute a coherent group. By characterizing HAX1 protein interactome using targeted approach, we attempt to explain HAX1 multiple functions and its role in the cell. Presented analyses indicate that HAX1 interacts weakly with a wide spectrum of proteins and its interactome tends to be cell-specific, which conforms to a profile of intrinsically disordered protein. Moreover, we have identified a mitochondrial subset of HAX1 protein partners and preliminarily characterized its involvement in the cellular response to oxidative stress and aggregation.

中文翻译：

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多功能HAX1蛋白的相互作用组表明其在调节能量代谢，解聚，细胞骨架组织和RNA加工中的作用。

HAX1是一种涉及许多细胞过程的多功能蛋白，包括细胞凋亡，细胞迁移和钙稳态，但其作用方式仍然不清楚。已经鉴定了多个HAX1蛋白伴侣，但是它们参与了许多不同的途径，形成了不同的复合物，并不构成一个连贯的基团。通过使用靶向方法表征HAX1蛋白质相互作用组，我们试图解释HAX1的多种功能及其在细胞中的作用。提出的分析表明，HAX1与多种蛋白质之间的相互作用较弱，并且其相互作用基因组倾向于是细胞特异性的，这与内在无序的蛋白质相符。此外，