Background Carpal tunnel syndrome (CTS) is a common upper limb entrapment neuropathy; severe cases are treated surgically and mild to moderate can be managed conservatively. The purpose of this systematic review and meta-analysis was to define the efficacy of gabapentin as an adjuvant to splinting in the treatment of mild to moderate CTS. Methods A systematic search through 13 databases, randomized clinical trials (RCTs) reporting the use of gabapentin with splinting in CTS were included and analyzed. Results Three RCTs including 170 patients were eligible. There was no significant difference between gabapentin plus splinting and splinting alone in 5 measured parameters: (1) Symptom Severity Scale (SSS) [MD (95% CI) = − 0.76 (− 2.46–0.93), p = 0.378], (2) Functional Status Scale (FSS) [MD (95% CI) = − 0.23 (− 1.40–0.94), p = 0.701], (3) visual analogue scale (VAS) to assess pain [MD (95% CI) = − 0.6 (− 1.47–0.27), p = 0.174], (4) Grip strength [MD (95% CI) = − 0.11 (− 0.70–0.48), p = 0.718], and (5) pinch strength [MD (95% CI) = 0.72 (− 0.10–1.54), p = 0.083]. Conclusion This review provides low-quality evidence that gabapentin plus nocturnal splinting is not superior to splinting alone. More high-quality trials are needed to determine the role of this drug as an adjuvant in the management of CTS.

中文翻译：

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加巴喷丁作为腕管综合征 (CTS) 夹板的辅助治疗：随机对照试验的系统评价和荟萃分析

背景腕管综合征（CTS）是一种常见的上肢卡压神经病；严重的病例通过手术治疗，轻到中度的可以保守治疗。本系统评价和荟萃分析的目的是确定加巴喷丁作为夹板辅助治疗轻中度 CTS 的疗效。方法 系统搜索了 13 个数据库，随机临床试验 (RCT) 报告了在 CTS 中使用加巴喷丁夹板的情况，并进行了分析。结果 包括 170 名患者在内的三项 RCT 符合条件。在 5 个测量参数中，加巴喷丁加夹板和单独夹板之间没有显着差异：(1) 症状严重程度 (SSS) [MD (95% CI) = − 0.76 (− 2.46–0.93), p = 0.378], (2) ) 功能状态量表 (FSS) [MD (95% CI) = − 0.23 (− 1.40–0.94), p = 0.701], (3) 评估疼痛的视觉模拟量表 (VAS) [MD (95% CI) = − 0.6 (− 1.47–0.27), p = 0.174], (4) 握力 [MD (95% CI) = − 0.11 ( − 0.70–0.48), p = 0.718] 和 (5) 挤压强度 [MD (95% CI) = 0.72 (− 0.10–1.54), p = 0.083]。结论 本综述提供了低质量的证据，证明加巴喷丁加夜间夹板并不优于单独夹板。需要更多高质量的试验来确定这种药物作为辅助治疗 CTS 的作用。