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The role of infectious pathogens in exacerbation of chronic obstructive pulmonary disease in Dakahlia Governorate
The Egyptian Journal of Bronchology ( IF 1.0 ) Pub Date : 2020-11-04 , DOI: 10.1186/s43168-020-00039-6
Elsayed Ahmed Fahmy , Heba Wagih Abdelwahab , Heba Elsayed Eldegla , Mohammed Khairy Fahmy Elbadrawy

Exacerbations of chronic obstructive pulmonary disease (COPD) represent important events in the management of COPD because of its negative impact on health status and disease progression. The etiology of acute exacerbations of chronic obstructive pulmonary disease (COPDAE) is heterogeneous and still under discussion. So, this study was planned to investigate the role of infectious pathogens (fungi and atypical mycobacteria in addition to the well-known bacteria) in patients with COPD exacerbation in our locality. This observational cross-sectional study was conducted on 100 patients with acute exacerbation of COPD. Sputum specimens were collected for mycobacterial and fungal examination in addition to routine sputum bacteriology. All sputum samples were negative for typical and atypical mycobacteria whereas sputum samples of 18 patients (18%) were negative for fungi. Mixed fungal growth was found in 19 patients (19%). Candida was isolated from 67 patients (67%), Aspergillus was isolated from 27 patients (27%), Alternaria was isolated from 3 patients (3%), and other fungi were isolated from 4 patients (4%). As regards sputum bacteriology, sputum samples of 49 patients (49%) have bacterial growth. Streptococcus pneumoniae was isolated from 16 samples (16%) and represents the most frequent bacterial isolate in this study. The present study indicates that typical and atypical mycobacteria have no role in COPD exacerbations in our locality. However, fungi and bacteria may have a role in COPD exacerbations.

中文翻译:

传染性病原体在大卡利亚省慢性阻塞性肺疾病恶化中的作用

慢性阻塞性肺疾病(COPD)的恶化代表了COPD管理中的重要事件,因为它对健康状况和疾病进展具有负面影响。慢性阻塞性肺疾病(COPDAE)急性加重的病因学是多种多样的,仍在讨论中。因此,本研究计划调查感染性病原体(除众所周知的细菌外,还有真菌和非典型分枝杆菌)在COPD恶化患者中的作用。这项观察性横断面研究是针对100例COPD急性加重患者进行的。除常规痰细菌学检查外,还收集痰标本进行分枝杆菌和真菌检查。所有痰液样本中典型和非典型分枝杆菌均​​为阴性,而18例患者(18%)的痰液样本中真菌为阴性。19名患者(19%)发现混合真菌生长。从67例患者中分离出念珠菌(67%),从27例患者中分离出曲霉菌(27%),从3例患者中分离出链霉菌(3%),从4例患者中分离出其他真菌(4%)。在痰细菌学方面,49名患者(49%)的痰标本中有细菌生长。肺炎链球菌是从16个样品中分离出来的(占16%),是本研究中最常见的细菌分离株。本研究表明典型和非典型的分枝杆菌在我们当地的COPD恶化中没有作用。但是,真菌和细菌可能在COPD恶化中起作用。从67例患者中分离出念珠菌(67%),从27例患者中分离出曲霉菌(27%),从3例患者中分离出链霉菌(3%),从4例患者中分离出其他真菌(4%)。在痰细菌学方面,49名患者(49%)的痰标本中有细菌生长。肺炎链球菌是从16个样品中分离出来的(占16%),是本研究中最常见的细菌分离株。本研究表明典型和非典型的分枝杆菌在我们当地的COPD恶化中没有作用。但是,真菌和细菌可能在COPD恶化中起作用。从67例患者中分离出念珠菌(67%),从27例患者中分离出曲霉菌(27%),从3例患者中分离出链霉菌(3%),从4例患者中分离出其他真菌(4%)。在痰细菌学方面,49名患者(49%)的痰标本中有细菌生长。肺炎链球菌是从16个样品中分离出来的(占16%),是本研究中最常见的细菌分离株。本研究表明典型和非典型的分枝杆菌在我们当地的COPD恶化中没有作用。但是,真菌和细菌可能在COPD恶化中起作用。49名患者(49%)的痰液样本中有细菌生长。肺炎链球菌是从16个样品中分离出来的(占16%),是本研究中最常见的细菌分离株。本研究表明典型和非典型的分枝杆菌在我们当地的COPD恶化中没有作用。但是,真菌和细菌可能在COPD恶化中起作用。49名患者(49%)的痰液样本中有细菌生长。肺炎链球菌是从16个样品中分离出来的(占16%),是本研究中最常见的细菌分离株。本研究表明典型和非典型的分枝杆菌在我们当地的COPD恶化中没有作用。但是,真菌和细菌可能在COPD恶化中起作用。
更新日期:2020-11-04
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