Everything in its right place: controlling the local composition of hydrogels using microfluidic traps,Lab on a Chip

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Everything in its right place: controlling the local composition of hydrogels using microfluidic traps
Lab on a Chip ( IF 6.1 ) Pub Date : 2020-10-28 , DOI: 10.1039/d0lc00691b
Michael Kessler _{1,

2,

3,

4,

5} , Hervé Elettro _{3,

4,

5,

6,

7} , Isabelle Heimgartner _{1,

2,

3,

4,

5} , Soujanya Madasu _{1,

2,

3,

4,

5} , Kenneth A. Brakke _{8,

9,

10,

11} , François Gallaire _{3,

4,

5,

6,

7} , Esther Amstad _{1,

2,

3,

4,

5}

Affiliation

Many natural materials display locally varying compositions that impart unique mechanical properties to them which are still unmatched by manmade counterparts. Synthetic materials often possess structures that are well-defined on the molecular level, but poorly defined on the microscale. A fundamental difference that leads to this dissimilarity between natural and synthetic materials is their processing. Many natural materials are assembled from compartmentalized reagents that are released in well-defined and spatially confined regions, resulting in locally varying compositions. By contrast, synthetic materials are typically processed in bulk. Inspired by nature, we introduce a drop-based technique that enables the design of microstructured hydrogel sheets possessing tuneable locally varying compositions. This control in the spatial composition and microstructure is achieved with a microfluidic Hele-Shaw cell that possesses traps with varying trapping strengths to selectively immobilize different types of drops. This modular platform is not limited to the fabrication of hydrogels but can be employed for any material that can be processed into drops and solidified within them. It likely opens up new possibilities for the design of structured, load-bearing hydrogels, as well as for the next generation of soft actuators and sensors.

中文翻译：

一切都在正确的位置：使用微流阱控制水凝胶的局部组成

许多天然材料显示出局部变化的成分，赋予它们独特的机械性能，而人造材料仍无法与之匹敌。合成材料通常具有在分子水平上定义明确但在微观尺度上定义不明确的结构。导致天然材料与合成材料之间存在这种差异的根本区别在于其加工方式。许多天然材料是由分隔的试剂组装而成的，这些试剂在确定的空间受限区域释放，从而导致局部变化的成分。相比之下，合成材料通常进行批量处理。受自然界的启发，我们引入了基于液滴的技术，该技术能够设计具有可调节的局部变化组成的微结构水凝胶片。这种空间组成和微结构的控制是通过微流体Hele-Shaw细胞实现的，该细胞具有具有不同捕获强度的陷阱，可以选择性地固定不同类型的液滴。该模块化平台不限于水凝胶的制造，而是可用于可被加工成液滴并在其中固化的任何材料。它可能为结构化，承重水凝胶的设计以及下一代软致动器和传感器开辟新的可能性。该模块化平台不限于水凝胶的制造，而是可用于可被加工成液滴并在其中固化的任何材料。它可能为结构化，承重水凝胶的设计以及下一代软致动器和传感器开辟新的可能性。该模块化平台不限于水凝胶的制造，而是可用于可被加工成液滴并在其中固化的任何材料。它可能为结构化，承重水凝胶的设计以及下一代软致动器和传感器开辟新的可能性。

更新日期：2020-11-04

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