Background: An accurate estimation of the duration of atrial fibrillation (AF) is critical for its safe management. Recent studies suggested that copeptin, carbohydrate antigen-125 (CA-125), galectin-3 and growth differentiation factor-15 (GDF-15) are increased in AF. We examined the ability of these markers to identify patients presenting with AF of ≤ 48 versus > 48 h duration.

Methods: Retrospective analysis of a prospective study that included patients with AF of known duration.

Results: 98 patients were analyzed, 47 with AF ≤48h and 51 with >48h. In patients presenting with AF of ≤ 48 versus > 48 h duration, the mean CA-125 concentration was 16.9±12.5 versus 30.9±36.3 U/mL (p=0.01), and GDF-15 concentration was 1320±889 versus 2608±2163 pg/mL (p<0.001). Copeptin concentration was not independently associated with AF duration. The Galectin-3 concentration did not differ between groups. Area under the ROC curve to identify patients with AF≤48h was 0.869 for CA-125, 0.853 for GDF-15.

Conclusion: The plasma concentrations of CA-125, GDF-15 and copeptin, but not Galectin-3, are higher in patients presenting with AF of > 48 h duration than in those with AF ≤ 48h. The ability to discriminate recent AF offered by CA-125 and GDF-15 seems high.

背景：准确估计房颤（AF）的持续时间对其安全管理至关重要。最近的研究表明，在房颤中，肽素，碳水化合物抗原125（CA-125），半乳凝素3和生长分化因子15（GDF-15）升高。我们检查了这些标记物识别AF持续时间≥48 h的患者的能力。

方法：回顾性分析一项前瞻性研究，该研究包括已知持续时间的房颤患者。

结果：分析了98例患者，其中AF≥48h的47例和> 48h的51例。在患者出现AF的持续时间为？48 vs> 48 h时，平均CA-125浓度为16.9±12.5 vs 30.9±36.3 U / mL（p = 0.01），GDF-15浓度为1320± 889和2608±2163 pg / mL（p <0.001）。Copeptin浓度与房颤持续时间无关。各组之间Galectin-3的浓度没有差异。ROC曲线下用于识别AF≥48h的患者CA-125为0.869，GDF-15为0.853。

结论：持续时间> 48 h的AF患者的血浆CA-125，GDF-15和copeptin，而非Galectin-3的血浆浓度高于AF≥48h的患者。区分CA-125和GDF-15提供的最近AF的能力似乎很高。