The literature on cognition in people with multiple sclerosis (MS) has grown exponentially over the last 25 years, and cognitive dysfunction is now recognized as a core symptom of the disease. Impairment of cognitive function is estimated to affect 34%–65% of adult patients1 and nearly 30% of patients under 18 years of age.2 MS-related cognitive impairment presents a considerable burden to patients, family members, and society due to the negative impact on function, including employment, daily living and social activity, and overall quality of life.1

中文翻译：

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了解 MS 认知变化的病理生理学：向前迈进了一步

在过去的 25 年中，关于多发性硬化症 (MS) 患者认知的文献呈指数级增长，认知功能障碍现在被认为是该疾病的核心症状。据估计，认知功能受损影响了 34%–65% 的成年患者 1 和近 30% 的 18 岁以下患者。 2 MS 相关的认知功能受损给患者、家庭成员和社会带来了相当大的负担对功能的影响，包括就业、日常生活和社交活动，以及整体生活质量。 1