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Chlamydia pneumoniae infection in patients hospitalised for community-acquired pneumonia in Southern Jordan
Indian Journal of Medical Microbiology ( IF 1.4 ) Pub Date : 2020-07-01 , DOI: 10.4103/ijmm.ijmm_20_63 Tahany Saleem Al-Hajaya 1 , Wael Ali Al-Zereini 1 , Hesham Mahmoud Al-Younes 2
Purpose: Chlamydia pneumoniae is associated with human respiratory diseases. Few reports examined the involvement of this bacterium in community-acquired pneumonia (CAP) in Jordan. This study investigates for the first time the role of C. pneumoniae in the establishment of CAP among nationals residing the southern part of Jordan. Materials and Methods: Nasopharyngeal and sera samples were collected from 70 hospitalised CAP patients and 63 healthy controls from Al-Karak Governorate and examined using the microimmunofluorescence and polymerase chain reaction techniques. The overall prevalence of C. pneumoniae infection was estimated by detecting the chlamydial immunoglobulin G (IgG) antibodies at a titre of 1:16. Rate of acute infection was estimated by detecting chlamydial DNA in nasopharyngeal samples and IgG and IgM at titres of 1:512 and 1:16, respectively. Results: A higher overall seroprevalence of C. pneumoniae IgG was detected in CAP patients than controls (44.3% vs. 30.2%). The rate of acute infection in the entire CAP patients, based on IgG titre of 1:512, was 7.14% compared to 1.58% in the controls. Approximately, three-fold increase in the rate of acute infection was observed in CAP cases, seropositive at IgG titre of 1:16, compared to seropositive controls (16.1% vs. 5.3%). Interestingly, chlamydial IgM antibodies were detectable in 27.1% compared to only 3.2% of the controls. The presence of chlamydial nucleic acids was confirmed in 40% of CAP patients and in 7.9% of controls. Conclusions: The present findings clearly suggest a role of C. pneumoniae in the aetiology of CAP in Southern Jordan. However, coinfections with other respiratory pathogens should not be excluded.
中文翻译：
约旦南部因社区获得性肺炎住院患者的肺炎衣原体感染情况
目的：肺炎衣原体与人类呼吸道疾病有关。很少有报告研究这种细菌与约旦社区获得性肺炎 (CAP) 的关系。本研究首次调查了肺炎衣原体在居住于约旦南部的国民中形成 CAP 中的作用。材料和方法：从卡拉克省 70 名住院 CAP 患者和 63 名健康对照中采集鼻咽和血清样本，并使用微量免疫荧光和聚合酶链反应技术进行检查。 C的总体患病率通过检测滴度为 1:16 的衣原体免疫球蛋白 G (IgG) 抗体来估计肺炎支原体感染。通过检测鼻咽样本中的衣原体 DNA 以及滴度分别为 1:512 和 1:16 的 IgG 和 IgM 来估计急性感染率。结果： CAP 患者中检测到的肺炎衣原体IgG 总体血清阳性率高于对照组（44.3% vs. 30.2%）。根据 IgG 滴度为 1:512，整个 CAP 患者的急性感染率为 7.14%，而对照组为 1.58%。与血清阳性对照组相比，在 IgG 滴度为 1:16 的血清阳性 CAP 病例中，观察到急性感染率大约增加了三倍（16.1% vs. 5.3%）。有趣的是，27.1% 的人可检测到衣原体 IgM 抗体，而对照人群中只有 3.2% 的人可检测到衣原体 IgM 抗体。 40% 的 CAP 患者和 7.9% 的对照者中证实存在衣原体核酸。结论：目前的研究结果清楚地表明肺炎衣原体在约旦南部 CAP 的病因学中发挥着重要作用。 然而，不应排除与其他呼吸道病原体的合并感染。
更新日期：2020-07-01
Indian Journal of Medical Microbiology ( IF 1.4 ) Pub Date : 2020-07-01 , DOI: 10.4103/ijmm.ijmm_20_63 Tahany Saleem Al-Hajaya 1 , Wael Ali Al-Zereini 1 , Hesham Mahmoud Al-Younes 2
Affiliation
Purpose: Chlamydia pneumoniae is associated with human respiratory diseases. Few reports examined the involvement of this bacterium in community-acquired pneumonia (CAP) in Jordan. This study investigates for the first time the role of C. pneumoniae in the establishment of CAP among nationals residing the southern part of Jordan. Materials and Methods: Nasopharyngeal and sera samples were collected from 70 hospitalised CAP patients and 63 healthy controls from Al-Karak Governorate and examined using the microimmunofluorescence and polymerase chain reaction techniques. The overall prevalence of C. pneumoniae infection was estimated by detecting the chlamydial immunoglobulin G (IgG) antibodies at a titre of 1:16. Rate of acute infection was estimated by detecting chlamydial DNA in nasopharyngeal samples and IgG and IgM at titres of 1:512 and 1:16, respectively. Results: A higher overall seroprevalence of C. pneumoniae IgG was detected in CAP patients than controls (44.3% vs. 30.2%). The rate of acute infection in the entire CAP patients, based on IgG titre of 1:512, was 7.14% compared to 1.58% in the controls. Approximately, three-fold increase in the rate of acute infection was observed in CAP cases, seropositive at IgG titre of 1:16, compared to seropositive controls (16.1% vs. 5.3%). Interestingly, chlamydial IgM antibodies were detectable in 27.1% compared to only 3.2% of the controls. The presence of chlamydial nucleic acids was confirmed in 40% of CAP patients and in 7.9% of controls. Conclusions: The present findings clearly suggest a role of C. pneumoniae in the aetiology of CAP in Southern Jordan. However, coinfections with other respiratory pathogens should not be excluded.
中文翻译：
约旦南部因社区获得性肺炎住院患者的肺炎衣原体感染情况
目的：肺炎衣原体与人类呼吸道疾病有关。很少有报告研究这种细菌与约旦社区获得性肺炎 (CAP) 的关系。本研究首次调查了肺炎衣原体在居住于约旦南部的国民中形成 CAP 中的作用。材料和方法：从卡拉克省 70 名住院 CAP 患者和 63 名健康对照中采集鼻咽和血清样本，并使用微量免疫荧光和聚合酶链反应技术进行检查。 C的总体患病率通过检测滴度为 1:16 的衣原体免疫球蛋白 G (IgG) 抗体来估计肺炎支原体感染。通过检测鼻咽样本中的衣原体 DNA 以及滴度分别为 1:512 和 1:16 的 IgG 和 IgM 来估计急性感染率。结果： CAP 患者中检测到的肺炎衣原体IgG 总体血清阳性率高于对照组（44.3% vs. 30.2%）。根据 IgG 滴度为 1:512，整个 CAP 患者的急性感染率为 7.14%，而对照组为 1.58%。与血清阳性对照组相比，在 IgG 滴度为 1:16 的血清阳性 CAP 病例中，观察到急性感染率大约增加了三倍（16.1% vs. 5.3%）。有趣的是，27.1% 的人可检测到衣原体 IgM 抗体，而对照人群中只有 3.2% 的人可检测到衣原体 IgM 抗体。 40% 的 CAP 患者和 7.9% 的对照者中证实存在衣原体核酸。结论：目前的研究结果清楚地表明肺炎衣原体在约旦南部 CAP 的病因学中发挥着重要作用。 然而，不应排除与其他呼吸道病原体的合并感染。
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