当前位置：
X-MOL 学术
›
Indian J. Med. Microbiol.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Prevalence of torch infections and its associated poor outcome in high-risk pregnant women of Central India: Time to think for prevention strategies
Indian Journal of Medical Microbiology ( IF 1.4 ) Pub Date : 2020-07-01 , DOI: 10.4103/ijmm.ijmm_20_136 H V Manjunathachar 1 , Kavita N Singh 2 , Vivek Chouksey 1 , Ravindra Kumar 3 , Ravendra K Sharma 4 , Pradip V Barde 5
Introduction: The TORCH infections during pregnancy are associated with adverse congenital abnormalities, poor foetal outcome and subsequent reproductive failures. The absence of baseline data on status of TORCH infections and associated foetal outcomes prompted us to conduct the current study in Central India. Materials and Methods: A total of 144 high-risk pregnant women attending tertiary care unit, suspected for TORCH infections were enrolled from August 2017 to December 2018. All the participants were tested for the presence of IgM and IgG antibodies and followed up to record the foetal outcome. Results: The overall TORCH infection (IgM positivity) positivity rate was 61.1% (88/144). Rubella was the most prevalent infection (46.5%) followed by herpes simplex virus (HSV) 1 and 2 (41%) and cytomegalovirus (CMV) (34.7%). The highest IgG sero-positivity was recorded against CMV (88.6%), followed by Rubella (86.8%), HSV 1 and 2 (28.4%), and toxoplasmosis (15.2%). Follow-up of IgM TORCH positive pregnant women revealed that majority of the neonates/infants are having congenital cardiac abnormalities (39.2%), followed by microcephaly/hydrocephaly (25%), low birth weight (10.7%), and deafness (3.6%). Thirty-two percent of neonatal mortality was associated to multiple TORCH infections. Conclusion: A high prevalence of IgM seropositivity of TORCH infection was noted in the present study with the increased rate of poor foetal outcome warrants the need of proper prenatal counselling, universal immunisation and nutritional supplements during pregnancy.
中文翻译：
印度中部高危孕妇火炬感染的患病率及其相关的不良后果：是时候考虑预防策略了
简介：怀孕期间的 TORCH 感染与不良先天畸形、胎儿不良结局和随后的生殖失败有关。由于缺乏 TORCH 感染状况和相关胎儿结局的基线数据，促使我们在印度中部进行当前的研究。材料与方法：2017年8月至2018年12月期间，共纳入144名在三级医疗机构就诊、疑似TORCH感染的高危孕妇。所有参与者均进行IgM和IgG抗体检测，并随访记录胎儿结局。结果：总体TORCH感染（IgM阳性）阳性率为61.1%（88/144）。风疹是最常见的感染 (46.5%)，其次是单纯疱疹病毒 (HSV) 1 和 2 (41%) 以及巨细胞病毒 (CMV) (34.7%)。针对 CMV 的 IgG 血清阳性率最高 (88.6%)，其次是风疹 (86.8%)、HSV 1 和 2 (28.4%) 以及弓形体病 (15.2%)。对IgM TORCH阳性孕妇的随访显示，大多数新生儿/婴儿患有先天性心脏异常（39.2%），其次是小头畸形/脑积水（25%）、低出生体重（10.7%）和耳聋（3.6%） ）。百分之三十二的新生儿死亡率与多重 TORCH 感染有关。结论：本研究指出，TORCH 感染 IgM 血清阳性率较高，胎儿不良结局发生率增加，需要适当的产前咨询、普遍免疫和孕期营养补充。
更新日期：2020-07-01
Indian Journal of Medical Microbiology ( IF 1.4 ) Pub Date : 2020-07-01 , DOI: 10.4103/ijmm.ijmm_20_136 H V Manjunathachar 1 , Kavita N Singh 2 , Vivek Chouksey 1 , Ravindra Kumar 3 , Ravendra K Sharma 4 , Pradip V Barde 5
Affiliation
Introduction: The TORCH infections during pregnancy are associated with adverse congenital abnormalities, poor foetal outcome and subsequent reproductive failures. The absence of baseline data on status of TORCH infections and associated foetal outcomes prompted us to conduct the current study in Central India. Materials and Methods: A total of 144 high-risk pregnant women attending tertiary care unit, suspected for TORCH infections were enrolled from August 2017 to December 2018. All the participants were tested for the presence of IgM and IgG antibodies and followed up to record the foetal outcome. Results: The overall TORCH infection (IgM positivity) positivity rate was 61.1% (88/144). Rubella was the most prevalent infection (46.5%) followed by herpes simplex virus (HSV) 1 and 2 (41%) and cytomegalovirus (CMV) (34.7%). The highest IgG sero-positivity was recorded against CMV (88.6%), followed by Rubella (86.8%), HSV 1 and 2 (28.4%), and toxoplasmosis (15.2%). Follow-up of IgM TORCH positive pregnant women revealed that majority of the neonates/infants are having congenital cardiac abnormalities (39.2%), followed by microcephaly/hydrocephaly (25%), low birth weight (10.7%), and deafness (3.6%). Thirty-two percent of neonatal mortality was associated to multiple TORCH infections. Conclusion: A high prevalence of IgM seropositivity of TORCH infection was noted in the present study with the increased rate of poor foetal outcome warrants the need of proper prenatal counselling, universal immunisation and nutritional supplements during pregnancy.
中文翻译：
印度中部高危孕妇火炬感染的患病率及其相关的不良后果：是时候考虑预防策略了
简介：怀孕期间的 TORCH 感染与不良先天畸形、胎儿不良结局和随后的生殖失败有关。由于缺乏 TORCH 感染状况和相关胎儿结局的基线数据，促使我们在印度中部进行当前的研究。材料与方法：2017年8月至2018年12月期间，共纳入144名在三级医疗机构就诊、疑似TORCH感染的高危孕妇。所有参与者均进行IgM和IgG抗体检测，并随访记录胎儿结局。结果：总体TORCH感染（IgM阳性）阳性率为61.1%（88/144）。风疹是最常见的感染 (46.5%)，其次是单纯疱疹病毒 (HSV) 1 和 2 (41%) 以及巨细胞病毒 (CMV) (34.7%)。针对 CMV 的 IgG 血清阳性率最高 (88.6%)，其次是风疹 (86.8%)、HSV 1 和 2 (28.4%) 以及弓形体病 (15.2%)。对IgM TORCH阳性孕妇的随访显示，大多数新生儿/婴儿患有先天性心脏异常（39.2%），其次是小头畸形/脑积水（25%）、低出生体重（10.7%）和耳聋（3.6%） ）。百分之三十二的新生儿死亡率与多重 TORCH 感染有关。结论：本研究指出，TORCH 感染 IgM 血清阳性率较高，胎儿不良结局发生率增加，需要适当的产前咨询、普遍免疫和孕期营养补充。
京公网安备 11010802027423号