We evaluated the incidence and risk factors of Staphylococcus aureus colonisation in 300 treatment-naïve HIV patients. Swabs from anterior nares and pharynx were cultured. Eighty-eight patients (29.3%) were colonised with S. aureus (47.7% nasal, 23.8% pharyngeal and 28.5% at both sites), which yielded 112 isolates. Methicillin-resistant S. aureus was detected in 25.9% (29/112) of isolates. Panton–Valentine leucocidin gene was present in 18.8% (21/112) of isolates. Multiple logistic regression analysis identified CD4 count <200 cells/mm³, public bath use, alcohol intake and other sexually transmitted infections as independent predictors for S. aureus colonisation. On follow-up, 22.7% of patients with S. aureus colonisation developed skin- and soft-tissue infections. Strategies for behavioural changes would be helpful in controlling S. aureus colonisation and subsequent infection.


中文翻译：

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HIV 感染者体内的金黄色葡萄球菌定植：发病率、危险因素以及随后的皮肤和软组织感染



我们评估了 300 名初治 HIV 患者中金黄色葡萄球菌定植的发生率和危险因素。培养前鼻孔和咽部的拭子。 88 名患者 (29.3%) 定植有金黄色葡萄球菌（47.7% 鼻腔、23.8% 咽部和 28.5% 两个部位），产生 112 个分离株。在 25.9% (29/112) 的分离株中检测到耐甲氧西林金黄色葡萄球菌。 Panton-Valentine leuucocidin 基因存在于 18.8% (21/112) 的分离株中。多重逻辑回归分析确定CD4计数<200 id=204>3、公共浴室的使用、酒精摄入和其他性传播感染是金黄色葡萄球菌定植的独立预测因素。随访中，22.7% 的金黄色葡萄球菌定植患者出现皮肤和软组织感染。行为改变策略将有助于控制金黄色葡萄球菌定植和随后的感染。