The crystal growth kinetics of piracetam, fenofibrate, phenylbutazone, acetaminophen, carbamazepine, and risperidone in methanol have been studied by two different methods; the isothermal seeded desupersaturation experiment (ISD) and the rotating disk technique (RD). Data has been collected in the range of temperature 288–303 K and at different supersaturations for the ISD experiments. The RD experiments were performed at constant supersaturation. In the ISD experiments, principal component analysis has been used to relate solution concentrations from IR measurements. An empirical power law equation has been fitted to the experimental desupersaturation data, and parameter values suggest surface integration control for all the APIs studied, a conclusion further supported by a separate mass transfer analysis. The order of rate of growth among the compounds and the magnitude of the growth rates determined by the two methods are in good agreement. In addition, the Burton Cabrera Frank (BCF) and Birth and Spread (B+S) surface integration models have been fitted to the ISD desupersaturation data, and average solid–liquid interfacial energies, mean diffusion distances, and surface mass transport rates have been estimated. An analysis of the experimental results and the growth rate parameters is performed to examine to what extent the difference in growth rate of different compounds can be rationalized.

中文翻译：

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药物化合物的晶体生长动力学

通过两种不同的方法研究了吡乙酰胺，非诺贝特，苯基丁a，对乙酰氨基酚，卡马西平和利培酮在甲醇中的晶体生长动力学；等温种子去饱和实验（ISD）和旋转盘技术（RD）。对于ISD实验，已经在288–303 K的温度范围内以及不同的过饱和度下收集了数据。RD实验在恒定的过饱和度下进行。在ISD实验中，主成分分析已用于关联红外测量中的溶液浓度。经验幂律方程已拟合到实验去饱和度数据，参数值建议对所有研究的API进行表面积分控制，这一结论进一步得到了单独的传质分析的支持。化合物之间的生长速率顺序和通过两种方法确定的生长速率的大小非常吻合。此外，Burton Cabrera Frank（BCF）和Birth and Spread（B + S）表面整合模型已经拟合到ISD超饱和数据中，并且平均固液界面能，平均扩散距离和表面质量传输速率已经达到。估计。对实验结果和生长速率参数进行分析，以检查不同化合物的生长速率差异在多大程度上可以合理化。估计了平均固液界面能，平均扩散距离和表面质量传输速率。对实验结果和生长速率参数进行分析，以检查不同化合物的生长速率差异在多大程度上可以合理化。估计了平均固液界面能，平均扩散距离和表面质量传输速率。对实验结果和生长速率参数进行分析，以检查不同化合物的生长速率差异在多大程度上可以合理化。