Controlled Nitric Oxide Release Using Poly(lactic-co-glycolic acid) Nanoparticles for Anti-Inflammatory Effects,Biomacromolecules

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Controlled Nitric Oxide Release Using Poly(lactic-co-glycolic acid) Nanoparticles for Anti-Inflammatory Effects
Biomacromolecules ( IF 5.5 ) Pub Date : 2020-11-04 , DOI: 10.1021/acs.biomac.0c01176
Yoogyeong Oh ₁ , Hyejoong Jeong ₁ , Sungmin Lim ₂ , Jinkee Hong ₁

Affiliation

Nitric oxide (NO) plays a key role in several physiological functions such as inflammatory responses and immune regulation. However, despite its beneficial functions, the short half-life and diffusion radius limit NO availability in biomedical applications. Hence, controlled release is important to achieve the desired therapeutic effects with exogenous NO delivery. In this study, we fabricated a poly(lactic-co-glycolic acid) (PLGA)-based NO delivery system to release NO in a sustained manner under physiological conditions. To prevent an initial burst release, branched polyethylenimine diazeniumdiolate (BPEI/NONOate), a pH-responsive NO donor, was encapsulated into the hydrophilic core of PLGA nanoparticles. Furthermore, low concentrations of NO released at a consistent level via a stabilization effect obtained as amine groups of BPEI/NONOate interacted with the nearby NONOate. Using the controlled-release profiles, we successfully regulated the inflammatory response in lipopolysaccharide-stimulated peripheral blood mononuclear cells. This work demonstrates the potential of a NO delivery carrier in the regulation of inflammation.

中文翻译：

使用聚乳酸-乙醇酸共聚物纳米颗粒控制一氧化氮释放，具有抗炎作用

一氧化氮（NO）在多种生理功能（例如炎症反应和免疫调节）中起关键作用。然而，尽管其有益的功能，半衰期短和扩散半径限制了生物医学应用中NO的可用性。因此，控释对于通过外源NO递送达到理想的治疗效果很重要。在这项研究中，我们制造了基于聚乳酸-乙醇酸（PLGA）的NO输送系统，以在生理条件下持续释放NO。为了防止最初的突然释放，将支链聚乙烯亚胺二氮烯二醇盐（BPEI / NONOate）（一种pH响应的NO供体）封装到PLGA纳米颗粒的亲水核中。此外，当BPEI / NONOate的胺基团与附近的NONOate相互作用时，通过稳定作用获得稳定浓度的低浓度NO。使用控释曲线，我们成功地调节了脂多糖刺激的外周血单核细胞中的炎症反应。这项工作证明了NO传递载体在调节炎症中的潜力。

更新日期：2020-12-14

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