Background: Psychiatric genetics has had limited success in translational efforts. A thorough understanding of the present state of translation in this field will be useful in the facilitation and assessment of future translational progress. Purpose: A narrative literature review was conducted. Combinations of 3 groups of terms were searched in EBSCOhost, Google Scholar, and PubMed. The review occurred in multiple steps, including abstract collection, inclusion/exclusion criteria review, coding, and analysis of included papers. Results: One hundred and fourteen articles were analyzed for the narrative review. Across those, 4 bottlenecks were noted that, if addressed, may provide insights and help improve and increase translation in the field of psychiatric genetics. These 4 bottlenecks are emphasizing linear translational frameworks, relying on molecular genomic findings, prioritizing certain psychiatric disorders, and publishing more reviews than experiments. Conclusions: These entwined bottlenecks are examined with one another. Awareness of these bottlenecks can inform stakeholders who work to translate and/or utilize psychiatric genetic information. Potential solutions include utilizing nonlinear translational frameworks as well as a wider array of psychiatric genetic information (e.g., family history and gene-environment interplay) in this area of research, expanding which psychiatric disorders are considered for translation, and when possible, conducting original research. Researchers are urged to consider how their research is translational in the context of the frameworks, genetic information, and psychiatric disorders discussed in this review. At a broader level, these efforts should be supported with translational efforts in funding and policy shifts.

中文翻译：

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转化精神病遗传学研究的四个可行的瓶颈和潜在解决方案：专家评审


背景：精神病遗传学在转化方面取得的成功有限。彻底了解该领域的翻译现状将有助于促进和评估未来的翻译进展。目的：进行叙述性文献综述。在 EBSCOhost、Google Scholar 和 PubMed 中搜索了 3 组术语的组合。审查分多个步骤进行，包括摘要收集、纳入/排除标准审查、编码和纳入论文的分析。结果：对 114 篇文章进行了分析以进行叙述性评论。其中指出了 4 个瓶颈，如果解决这些瓶颈，可能会提供见解并有助于改善和增加精神遗传学领域的转化。这 4 个瓶颈强调线性翻译框架、依赖分子基因组发现、优先考虑某些精神疾病以及发表的评论多于实验。结论：对这些相互交织的瓶颈进行了检验。对这些瓶颈的认识可以告知致力于翻译和/或利用精神病遗传信息的利益相关者。潜在的解决方案包括在该研究领域利用非线性翻译框架以及更广泛的精神科遗传信息（例如家族史和基因-环境相互作用），扩大考虑翻译的精神疾病，并在可能的情况下进行原创研究。研究人员被敦促考虑他们的研究如何在本综述中讨论的框架、遗传信息和精神疾病的背景下进行转化。在更广泛的层面上，这些努力应该得到资金和政策转变方面的转化努力的支持。