ABSTRACT

This study aimed to determine if older adults “at-risk” for dementia (those with MCI or SMC) exhibit accelerated long-term forgetting (ALF) and whether rate of forgetting (RoF) is associated with sleep efficiency, hippocampal volume and demographic/clinical features. Forty-nine “at-risk” participants and eighteen controls underwent examination. Memory was assessed using the Scene Memory Task (SMT) and WMS-III Logical Memory (LM) subtest. Tests were administered at baseline, 24 hours and 2 weeks. While our study did not find ALF in those “at-risk” for dementia, on the SMT, RoF over 24 hours and 2 weeks was negatively correlated with sleep efficiency. For LM, RoF at 2 weeks was moderately associated with left hippocampal volume. Neither visual or verbal RoF was correlated with demographic or clinical variables (age, MMSE, IQ, GDS-15). While ALF was not observed in this sample, our results suggest that visual and verbal forgetting have differential predictors.

摘要

本研究旨在确定老年人（患有 MCI 或 SMC 的老年人）是否表现出加速的长期遗忘 (ALF) 以及遗忘率 (RoF) 是否与睡眠效率、海马体积和人口统计相关。临床表现。49 名“有风险”的参与者和 18 名对照接受了检查。使用场景记忆任务 (SMT) 和 WMS-III 逻辑记忆 (LM) 子测试评估记忆。在基线、24 小时和 2 周时进行测试。虽然我们的研究没有在痴呆症“高危”人群中发现 ALF，但在 SMT 上，超过 24 小时和 2 周的 RoF 与睡眠效率呈负相关。对于 LM，2 周时的 RoF 与左侧海马体积中度相关。视觉或语言 RoF 均与人口统计学或临床变量（年龄、MMSE、IQ、GDS-15）无关。