Abstract

Interleukin (IL)-27, a member of the IL-6/IL-12 family, has an important role in modulating inflammation in partnership with innate and adaptive immune cells. IL-27 binding to IL-27R starts downstream signaling based on the target cells. It can instigate inflammation by inducing CD4⁺ T cell proliferation, Th1 polarization, cytotoxic T cell activation, generation of the natural killer cell, and macrophage and dendritic cell activation. However, by inducing programmed cell death and suppression of effector cells, IL-27 can suppress inflammation and return the immune response to hemostasis. Altogether, IL-27 displays multifaceted dual functions, which may result in either pro- or anti-inflammatory effects. Recent investigations indicated the antitumor activity of IL-27 via inducing Th1, and CTL responses and generating NK cells. On the other hand, IL-27 also can promote tumor cells' proliferation, survival, and angiogenesis. In the present review, we'll discuss recent advances concerning the role of IL-27 in inflammatory diseases such as infections, autoimmune diseases with a focus on cancer.

摘要

白细胞介素 (IL)-27 是 IL-6/IL-12 家族的成员，在与先天性和适应性免疫细胞合作调节炎症方面具有重要作用。IL-27 与 IL-27R 的结合开始基于靶细胞的下游信号传导。它可以通过诱导 CD4 ⁺引发炎症T 细胞增殖、Th1 极化、细胞毒性 T 细胞活化、自然杀伤细胞的产生以及巨噬细胞和树突细胞的活化。然而，通过诱导程序性细胞死亡和抑制效应细胞，IL-27 可以抑制炎症并使免疫反应恢复到止血状态。总之，IL-27 显示出多方面的双重功能，这可能导致促炎或抗炎作用。最近的研究表明 IL-27 通过诱导 Th1 和 CTL 反应并产生 NK 细胞具有抗肿瘤活性。另一方面，IL-27还可以促进肿瘤细胞的增殖、存活和血管生成。在本综述中，我们将讨论有关 IL-27 在炎症性疾病（如感染、自身免疫性疾病）中的作用的最新进展，重点是癌症。