The discovery and development of active compounds to eliminate drug resistance and side effects is a crucial process. In this study, the leaf infusion of Dracocephalum kotschyi Boiss as a novel green alternative is used to synthesize silver nanoparticles (Drac‐AgNPs). Antibacterial, cytotoxicity effects, hemocompatibility, and the catalytic properties of these nanoparticles are evaluated. The synthesis of Drac‐AgNPs is confirmed by UV–vis spectroscopy, X‐ray diffraction, Fourier‐transform infrared spectroscopy, and transmission electron microscopy, where Drac‐AgNPs are spherical, with a size range of 5–63 nm. Their IC₅₀ values against H1299 and MCF‐7 cell lines are above 50 and 100 μg mL⁻¹, respectively. Drac‐AgNPs are effective against an inclusive range of the gram‐positive and gram‐negative bacteria, that is, Staphylococcus epidermidis, Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Serratia marcescens, and Pseudomonas aeruginosa, and a low hemolytic effect makes them an exceptional AgNP with a great hemocompatibility. They show a moderate catalytic‐effect in terms of removing methylene blue, with 67% degradation. Altogether, Drac‐AgNP, as a multi‐tasker material, shows potential for the prevention and treatment of infections and photothermal/chemotherapy of cancers.

中文翻译：

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青兰叶浸液绿色合成银纳米颗粒的生物活性和催化活性

发现和开发活性化合物以消除耐药性和副作用是一个至关重要的过程。在这项研究中，青兰叶浸液作为一种新型绿色替代品被用来合成银纳米粒子（Drac-AgNPs）。评估了这些纳米颗粒的抗菌、细胞毒性作用、血液相容性和催化特性。Drac-AgNPs 的合成通过紫外可见光谱、X 射线衍射、傅里叶变换红外光谱和透射电子显微镜证实，其中 Drac-AgNPs 呈球形，尺寸范围为 5-63 nm。它们针对H1299和MCF-7细胞系的IC ₅₀值分别高于50和100 μg mL ^-1。Drac-AgNPs 可有效对抗多种革兰氏阳性和革兰氏阴性细菌，即表皮葡萄球菌、金黄色葡萄球菌、枯草芽孢杆菌、大肠杆菌、粘质沙雷氏菌和铜绿假单胞菌，并且低溶血作用使其成为特殊的 AgNP 具有良好的血液相容性。它们在去除亚甲基蓝方面表现出中等的催化效果，降解率为 67%。总而言之，Drac-AgNP 作为一种多任务材料，显示出预防和治疗感染以及癌症光热/化疗的潜力。