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Autophagy in T‐cell differentiation, survival and memory
Immunology and Cell Biology ( IF 3.2 ) Pub Date : 2020-11-03 , DOI: 10.1111/imcb.12422
Liqing Wang 1, 2 , Jugal Kishore Das 1 , Anil Kumar 1 , Hao-Yun Peng 1, 2 , Yijie Ren 1 , Xiaofang Xiong 1 , Jin-Ming Yang 3 , Jianxun Song 1
Affiliation  

Over the past decade, autophagy has emerged as a critical regulatory mechanism of the immune system through critically controlling various aspects of T cell biology and determining the fate of different T cell subsets. Autophagy maintains T cell development and survival by regulating the degradation of organelles and apoptotic proteins. The autophagic process also impacts the formation of memory T cells. Alteration of autophagy in T cells may lead to a variety of pathological conditions such as inflammation, autoimmune diseases and cancer. In this review, we discuss how autophagy impacts T cell differentiation, survival and memory, and its implication in immunotherapy for various diseases.

中文翻译:

自噬在 T 细胞分化、存活和记忆中的作用

在过去的十年中,自噬通过严格控制 T 细胞生物学的各个方面并确定不同 T 细胞亚群的命运,已成为免疫系统的关键调节机制。自噬通过调节细胞器和凋亡蛋白的降解来维持 T 细胞的发育和存活。自噬过程也会影响记忆 T 细胞的形成。T 细胞自噬的改变可能导致多种病理状况,例如炎症、自身免疫性疾病和癌症。在这篇综述中,我们讨论了自噬如何影响 T 细胞分化、存活和记忆,及其在各种疾病免疫治疗中的意义。
更新日期:2020-11-03
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