当前位置：
X-MOL 学术
›
J. Heterocycl. Chem.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Design, synthesis, and antifungal evaluation of novel coumarin‐pyrrole hybrids
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-11-03 , DOI: 10.1002/jhet.4180 Shuguang Zhang 1 , Xin Tan 1 , Chaogen Liang 1 , Weihua Zhang 1
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-11-03 , DOI: 10.1002/jhet.4180 Shuguang Zhang 1 , Xin Tan 1 , Chaogen Liang 1 , Weihua Zhang 1
Affiliation
|
A series of coumarin derivatives bearing a pyrrole scaffold were designed, prepared, and assessed for their in vitro antifungal activities against six phytopathogenic fungi. The antifungal activity screening results suggest that some synthesized hybrids exhibited potential fungicidal activities against the tested fungi. In particular, compounds 6j, 6k, 6o, 6p, and 6r displayed significant antifungal effects against Rhizoctorzia solani, and possessed EC50 values of 3.94, 7.75, 6.38, 6.25, and 7.67 μg/ mL, respectively. The above activities are more potent than the commercialized fungicide Boscalid (11.52 μg/mL) and Osthole (9.79 μg/mL). These results provide a significant reference for further rational design of coumarin‐based fungicides.
中文翻译：
新型香豆素-吡咯杂化物的设计，合成和抗真菌评估
设计，制备了一系列带有吡咯骨架的香豆素衍生物，并评估了它们对六种植物病原真菌的体外抗真菌活性。抗真菌活性筛选结果表明，一些合成的杂种对被测真菌表现出潜在的杀真菌活性。特别是，化合物6j，6k，6o，6p和6r表现出了对茄状根瘤菌的显着抗真菌作用，并具有EC 50值分别为3.94、7.75、6.38、6.25和7.67μg/ mL。上述活性比商品化杀菌剂Boscalid（11.52μg/ mL）和Osthole（9.79μg/ mL）更有效。这些结果为进一步合理设计基于香豆素的杀菌剂提供了重要参考。
更新日期：2020-11-03
中文翻译：
新型香豆素-吡咯杂化物的设计，合成和抗真菌评估
设计，制备了一系列带有吡咯骨架的香豆素衍生物，并评估了它们对六种植物病原真菌的体外抗真菌活性。抗真菌活性筛选结果表明，一些合成的杂种对被测真菌表现出潜在的杀真菌活性。特别是，化合物6j，6k，6o，6p和6r表现出了对茄状根瘤菌的显着抗真菌作用，并具有EC 50值分别为3.94、7.75、6.38、6.25和7.67μg/ mL。上述活性比商品化杀菌剂Boscalid（11.52μg/ mL）和Osthole（9.79μg/ mL）更有效。这些结果为进一步合理设计基于香豆素的杀菌剂提供了重要参考。
京公网安备 11010802027423号