High strength and bioactivity polyvinyl alcohol/collagen composite hydrogel with tannic acid as cross‐linker,Polymer Engineering and Science

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High strength and bioactivity polyvinyl alcohol/collagen composite hydrogel with tannic acid as cross‐linker
Polymer Engineering and Science ( IF 3.2 ) Pub Date : 2020-11-03 , DOI: 10.1002/pen.25574
Zhongxiang Bai _{1,

2} , Tianyou Wang ₁ , Xin Zheng ₁ , Yanping Huang ₁ , Yining Chen ₁ , Weihua Dan ₁

Affiliation

Hydrogels have great potential applications in biomedical materials, but their applications in complex physiological environments are severely limited by their weak strength and biotoxicity. Generally, synthetic polymer hydrogels and natural polymer hydrogels have complementary advantages in terms of mechanical strength and biological activity. Herein, tannic acid (TA), a natural material, was introduced into the polyvinyl alcohol/collagen (PVA‐COL) double network to prepare a hydrogel (PVA‐COL‐TA) with good bioactivity and mechanical properties. The tensile strength of the composite hydrogel can reach up to 20 times that of the pure PVA hydrogel. And the hydrogel after swelling under physiological conditions also exhibits stable mechanical properties. The introduction of TA can reduce the degradation rate of COL, enabling it to continue to exert biological activity. in vitro cytocompatibility experiments showed that PVA‐COL‐TA hydrogel has good sustained biological activity and the potential for biomedical materials.

中文翻译：

以鞣酸为交联剂的高强度和生物活性聚乙烯醇/胶原复合水凝胶

水凝胶在生物医学材料中具有巨大的潜在应用，但由于其强度和生物毒性较弱，它们在复杂生理环境中的应用受到严重限制。通常，就机械强度和生物活性而言，合成聚合物水凝胶和天然聚合物水凝胶具有互补的优点。在此，将天然物质鞣酸（TA）引入聚乙烯醇/胶原（PVA-COL）双网络中，以制备具有良好生物活性和机械性能的水凝胶（PVA-COL-TA）。复合水凝胶的抗张强度可以达到纯PVA水凝胶的20倍。并且在生理条件下溶胀后的水凝胶也表现出稳定的机械性能。引入TA可以降低COL的降解率，使它能够继续发挥生物活性。体外细胞相容性实验表明，PVA-COL-TA水凝胶具有良好的持续生物活性，并具有生物医学材料的潜力。

更新日期：2021-01-12

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