Cascade genetic testing is essential to clarify cancer risk in families with hereditary breast and ovarian cancer syndrome (HBOC) due to pathogenic variants (PVs) in BRCA1 or BRCA2. To date, data suggest that family communication of genetic testing results, with or without the aid of clinical resources such as a provider-written family letter, is impacted by multiple barriers. These barriers eventually lead to sub-optimal uptake of cascade genetic testing. We designed a 2-min animated video that a proband can share with relatives to notify them that the proband has tested positive for a pathogenic variant in BRCA1 or BRCA2. We studied the video via hypothetical scenario in an unselected population to simulate the process by which a relative receives unsolicited genetics information about their family member. We assessed the impact of the video on three specific domains: knowledge, cognitive message processing, and affective reactions. A total of 399 participants recruited through Amazon Mechanical Turk completed the study, and 373 were analyzed. The video significantly improved content knowledge/recall (p < .0001) from pre- to post-video viewing, indicating effective message communication. Items used to measure cognitive processing showed preliminary tendencies toward systematic message processing, which could be desired in familial communication aimed at initiating a specific action—in this case, cascade genetic testing. A majority of participants (66%) reported positive affective reaction as they indicated that they would feel gratitude if they received the video message from a relative, and did not evidence a negative affective reaction to receiving the information. Our data suggest that a video message can effectively communicate information about cascade genetic testing to potential relatives with as little as two minutes of content. Our data suggest that video messaging to assist family communication is a reasonable approach that increases understanding and is unlikely to cause harm.

中文翻译：

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级联测试视频对接收者知识、认知信息处理和情感反应的影响：形成性评估

由于BRCA1或BRCA2 中的致病变异 (PV)，级联基因检测对于阐明遗传性​​乳腺癌和卵巢癌综合征 (HBOC) 家族的癌症风险至关重要。迄今为止，数据表明基因检测结果的家庭交流，无论是否有临床资源的帮助，例如提供者写的家庭信，都会受到多种障碍的影响。这些障碍最终导致级联基因检测的次优应用。我们设计了一个 2 分钟的动画视频，先证者可以与亲属分享，通知他们先证者的BRCA1或BRCA2致病性变异检测呈阳性. 我们通过在未经选择的人群中的假设场景研究了视频，以模拟亲属接收有关其家庭成员的未经请求的遗传信息的过程。我们评估了视频对三个特定领域的影响：知识、认知信息处理和情感反应。通过 Amazon Mechanical Turk 招募的总共 399 名参与者完成了这项研究，并对 373 人进行了分析。该视频显着提高了内容知识/回忆（p < .0001) 从视频观看前到观看后，表明有效的信息交流。用于测量认知处理的项目显示出系统信息处理的初步趋势，这在旨在启动特定动作的家庭交流中可能是需要的——在这种情况下，级联基因测试。大多数参与者 (66%) 报告了积极的情感反应，因为他们表示，如果他们收到亲戚的视频信息，他们会感到感激，并且没有证明收到信息后有消极的情感反应。我们的数据表明，视频信息可以通过短短两分钟的内容有效地向潜在亲属传达有关级联基因检测的信息。