当前位置: X-MOL 学术Hippocampus › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Bidirectional modulation of hippocampal and amygdala synaptic plasticity by post‐weaning obesogenic diet intake in male rats: Influence of the duration of diet exposure
Hippocampus ( IF 2.4 ) Pub Date : 2020-11-04 , DOI: 10.1002/hipo.23278
Rose-Marie Vouimba 1, 2 , Ioannis Bakoyiannis 1, 3 , Eva-Gunnel Ducourneau 1, 3 , Mouna Maroun 4 , Guillaume Ferreira 1, 3
Affiliation  

Obesity is a chronic condition associated with adverse memory and emotional outcomes in humans and animal models. We have recently demonstrated that post‐weaning (i.e., periadolescent) high‐fat diet (HFD)‐induced obesity has opposite effect on hippocampal and amygdala‐dependent memory in rodents: while HFD consumption impairs spatial and relational memory, it enhances cue‐dependent emotional memory. However, it is still not clear whether this bidirectional HFD effect on memory is related to bidirectional alterations of hippocampal and amygdala synaptic plasticity and if it is influenced by the duration of diet intake. In the current study, we compared in male rats the impact of 2–3 and 6–7 months of HFD intake starting at weaning, thus covering adolescence, on in vivo long‐term potentiation (LTP) recorded simultaneously in the hippocampal area CA1 and the basolateral amygdala (BLA). As expected, 6–7 months of HFD intake abolished LTP in the CA1 and enhanced LTP in the BLA. However, 2–3 months of of HFD exposure enhanced LTP in both CA1 and BLA suggesting a transient compensatory mechanism in hippocampus. These results indicate that post‐weaning HFD intake progressively leads to bidirectional modulation of hippocampal and amygdala synaptic plasticity, as we previously demonstrated for related memory processes, yet with a different temporal dynamic.

中文翻译:

雄性大鼠断奶后致肥胖饮食摄入对海马和杏仁核突触可塑性的双向调节:饮食暴露持续时间的影响

肥胖是一种与人类和动物模型中的不良记忆和情绪结果相关的慢性疾病。我们最近证明,断奶后(即青春期)高脂饮食(HFD)诱导的肥胖对啮齿动物的海马和杏仁核依赖性记忆有相反的影响:虽然食用 HFD 会损害空间和关系记忆,但它会增强线索依赖性情感记忆。然而,尚不清楚这种双向 HFD 对记忆的影响是否与海马和杏仁核突触可塑性的双向改变有关,以及是否受饮食摄入持续时间的影响。在目前的研究中,我们比较了雄性大鼠在断奶时开始摄入 2-3 个月和 6-7 个月的 HFD 的影响,从而涵盖了青春期,在海马区 CA1 和基底外侧杏仁核 (BLA) 中同时记录的体内长时程增强 (LTP)。正如预期的那样,6-7 个月的 HFD 摄入量消除了 CA1 中的 LTP 并增强了 BLA 中的 LTP。然而,2-3 个月的 HFD 暴露增强了 CA1 和 BLA 中的 LTP,表明海马中存在短暂的补偿机制。这些结果表明,断奶后的 HFD 摄入逐渐导致海马和杏仁核突触可塑性的双向调节,正如我们之前对相关记忆过程所证明的那样,但具有不同的时间动态。2-3 个月的 HFD 暴露增强了 CA1 和 BLA 中的 LTP,表明海马中存在短暂的补偿机制。这些结果表明,断奶后的 HFD 摄入逐渐导致海马和杏仁核突触可塑性的双向调节,正如我们之前对相关记忆过程所证明的那样,但具有不同的时间动态。2-3 个月的 HFD 暴露增强了 CA1 和 BLA 中的 LTP,表明海马中存在短暂的补偿机制。这些结果表明,断奶后的 HFD 摄入逐渐导致海马和杏仁核突触可塑性的双向调节,正如我们之前对相关记忆过程所证明的那样,但具有不同的时间动态。
更新日期:2020-11-04
down
wechat
bug