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Dendrobium nobile Lindl alkaloid attenuates 6-OHDA-induced dopamine neurotoxicity
Biotechnology and Applied Biochemistry ( IF 3.2 ) Pub Date : 2020-11-04 , DOI: 10.1002/bab.2071 Dai-di Li 1 , Guo-Qing Wang 1 , Qin Wu 1 , Jing-Shan Shi 1 , Feng Zhang 1
Biotechnology and Applied Biochemistry ( IF 3.2 ) Pub Date : 2020-11-04 , DOI: 10.1002/bab.2071 Dai-di Li 1 , Guo-Qing Wang 1 , Qin Wu 1 , Jing-Shan Shi 1 , Feng Zhang 1
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Parkinson's disease (PD) is one of the most common central nervous system (CNS) degenerative disease and is characterized by a progressive loss of midbrain substantia nigra dopamine (DA) neurons. Dendrobium nobileLindl alkaloid (DNLA) is an active component extracted from D. nobile Lindl, which is a traditional Chinese herb. The various pharmacological effects of D. nobile are beneficial for human health. Recently, DNLA-mediated neuroprotective effects have been reported. However, the neuroprotection of DNLA on 6-hydroxydopamine (6-OHDA)-induced DA neurotoxicity is still unknown. This study aimed to explore the neuroprotective effects of DNLA on DA neurotoxicity induced by 6-OHDA. In PD rat model, continuous intragastric administration of DNLA (20 mg/kg) for 7 days significantly ameliorated 6-OHDA-induced DA neurons loss in the midbrain substantia nigra. In addition, primary rat midbrain neuron-glia cocultures were used to explore the mechanisms underlying DNLA-related DA neuroprotection. The studies on neuron-glia cocultures revealed that neuroprotective effects of DNLA (2.5 ng/mL) were mediated by inhibiting the release of proinflammatory cytokines. Taken together, DNLA holds neuroprotective effect on 6-OHDA-induced neurons neurodegeneration by selectively inhibiting the production of proinflammatory factors and could be a potential compound for PD treatment.
中文翻译：
石斛林德尔生物碱减弱 6-OHDA 诱导的多巴胺神经毒性
帕金森病 (PD) 是最常见的中枢神经系统 (CNS) 退行性疾病之一，其特征是中脑黑质多巴胺 (DA) 神经元进行性丧失。石斛石斛生物碱（DNLA）是从传统中草药石斛石斛中提取的活性成分。D. nobile的各种药理作用对人体健康有益。最近，已经报道了 DNLA 介导的神经保护作用。然而，DNLA 对 6-羟基多巴胺 (6-OHDA) 诱导的 DA 神经毒性的神经保护作用仍然未知。本研究旨在探讨DNLA对6-OHDA诱导的DA神经毒性的神经保护作用。在 PD 大鼠模型中，连续灌胃 DNLA (20 mg/kg) 7 天显着改善了 6-OHDA 诱导的中脑黑质 DA 神经元损失。此外，原代大鼠中脑神经元-胶质细胞共培养物用于探索 DNLA 相关 DA 神经保护的机制。对神经元-胶质细胞共培养的研究表明，DNLA (2.5 ng/mL) 的神经保护作用是通过抑制促炎细胞因子的释放来介导的。综合起来，
更新日期：2020-11-04
中文翻译：
石斛林德尔生物碱减弱 6-OHDA 诱导的多巴胺神经毒性
帕金森病 (PD) 是最常见的中枢神经系统 (CNS) 退行性疾病之一，其特征是中脑黑质多巴胺 (DA) 神经元进行性丧失。石斛石斛生物碱（DNLA）是从传统中草药石斛石斛中提取的活性成分。D. nobile的各种药理作用对人体健康有益。最近，已经报道了 DNLA 介导的神经保护作用。然而，DNLA 对 6-羟基多巴胺 (6-OHDA) 诱导的 DA 神经毒性的神经保护作用仍然未知。本研究旨在探讨DNLA对6-OHDA诱导的DA神经毒性的神经保护作用。在 PD 大鼠模型中，连续灌胃 DNLA (20 mg/kg) 7 天显着改善了 6-OHDA 诱导的中脑黑质 DA 神经元损失。此外，原代大鼠中脑神经元-胶质细胞共培养物用于探索 DNLA 相关 DA 神经保护的机制。对神经元-胶质细胞共培养的研究表明，DNLA (2.5 ng/mL) 的神经保护作用是通过抑制促炎细胞因子的释放来介导的。综合起来，
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