Glioma Therapy: Oncogenic State and Cell Identity Combinatorially Dictate the Susceptibility of Cells within Glioma Development Hierarchy to IGF1R Targeting (Adv. Sci. 21/2020),Advanced Science

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Glioma Therapy: Oncogenic State and Cell Identity Combinatorially Dictate the Susceptibility of Cells within Glioma Development Hierarchy to IGF1R Targeting (Adv. Sci. 21/2020)
Advanced Science ( IF 14.3 ) Pub Date : 2020-11-04 , DOI: 10.1002/advs.202070121
Anhao Tian , Bo Kang , Baizhou Li , Biying Qiu , Wenhong Jiang , Fangjie Shao , Qingqing Gao , Rui Liu , Chengwei Cai , Rui Jing , Wei Wang , Pengxiang Chen , Qinghui Liang , Lili Bao , Jianghong Man , Yan Wang , Yu Shi , Jin Li , Minmin Yang , Lisha Wang , Jianmin Zhang , Simon Hippenmeyer , Junming Zhu , Xiuwu Bian , Ying‐Jie Wang , Chong Liu

In article number 2001724, Chong Liu and co‐workers describe that the oncogenic state and cell identity need to match precisely to sensitize a glioma cell to IGF1R targeting. This phenomenon parallels the Chinese mortise and tenon joint structure, where different wood pieces are connected precisely by their mortise and tenon joints. Destruction of the mortise‐and‐tenon work (resembles the glioma hierarchy) needs the knowledge of how such structure is built up.

更新日期：2020-11-04

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