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3D Liver Models: Biofabrication of Hepatic Constructs by 3D Bioprinting of a Cell‐Laden Thermogel: An Effective Tool to Assess Drug‐Induced Hepatotoxic Response (Adv. Healthcare Mater. 21/2020)
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-11-04 , DOI: 10.1002/adhm.202070078
Manuele Gori , Sara M. Giannitelli , Miranda Torre , Pamela Mozetic , Franca Abbruzzese , Marcella Trombetta , Enrico Traversa , Lorenzo Moroni , Alberto Rainer

In article number 2001163, Alberto Rainer and co‐workers propose a semi‐synthetic thermoresponsive hydrogel system for the direct‐write bioprinting of hepatic cells. The resulting 3D model outperforms conventional 2D cultures in terms of liver‐specific metabolism and susceptibility to a known hepatotoxic compound.
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中文翻译:

3D肝模型:通过载有细胞的热凝胶的3D生物打印对肝结构进行生物制造:评估药物诱导的肝毒性反应的有效工具(Adv。Healthcare Mater。21/2020)

在2001163号文章中,Alberto Rainer及其同事提出了一种半合成的热响应水凝胶系统,用于直接写肝细胞的生物打印。最终的3D模型在肝脏特异性代谢和对已知肝毒性化合物的敏感性方面优于传统2D培养。
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更新日期:2020-11-04
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