Carbon Nanotubes: Construction of Aptamer‐siRNA Chimera/PEI/5‐FU/Carbon Nanotube/Collagen Membranes for the Treatment of Peritoneal Dissemination of Drug‐Resistant Gastric Cancer (Adv. Healthcare Mater. 21/2020),Advanced Healthcare Materials

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Carbon Nanotubes: Construction of Aptamer‐siRNA Chimera/PEI/5‐FU/Carbon Nanotube/Collagen Membranes for the Treatment of Peritoneal Dissemination of Drug‐Resistant Gastric Cancer (Adv. Healthcare Mater. 21/2020)
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-11-04 , DOI: 10.1002/adhm.202070080
Wen Chen , Sainan Yang , Xia Wei , Zailin Yang , Dongxu Liu , Xin Pu , Silian He , Yong Zhang

In article number 2001153 by Yong Zhang and co‐workers, aptamer‐siRNA Chimera/PEI/5‐FU/carbon nanotube (CNT)/collagen membranes are constructed to treat peritoneal dissemination of drug‐resistant gastric cancer. Chimeras can specifically bind to gastric cancer cells, then 5‐FU and chimeras are released. Chimeras are cut into siRNA by Dicer, which mediates targeted mRNA degradation.

中文翻译：

碳纳米管：Aptamer-siRNA Chimera / PEI / 5-FU /碳纳米管/胶原膜的构建，用于治疗抗药性胃癌的腹膜扩散（Adv。Healthcare Mater。21/2020）

Yong Zhang及其同事在编号为2001153的文章中，构建了适体siRNA Chimera / PEI / 5-FU /碳纳米管（CNT）/胶原膜来治疗耐药性胃癌的腹膜扩散。嵌合体可以与胃癌细胞特异性结合，然后释放5-FU和嵌合体。嵌合体被切酶切成siRNA，介导靶向的mRNA降解。

更新日期：2020-11-04

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