Abstract An efficient protocol for the synthesis of N-protected formamides employing nano TiO2 as a catalyst was achieved. The isocyanates formed by the Curtius rearrangement of N-protected acyl azides, were treated with formic acid in the presence of catalytic amount of nano TiO2 to yield the formamides. Further, these formamides were utilized for the synthesis of biologically active thioformamides. The synthesized N-protected formamides and thioformamides were characterized by IR, 1H NMR, 13C NMR and HRMS. The target molecules were subjected to in vitro antibacterial and antifungal activities. Hydrothermal method was followed for the preparation of nano TiO2, and was confirmed by XRD, FTIR, SEM, EDX and TEM techniques.

中文翻译：

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采用纳米二氧化钛的生物活性 N 保护甲酰胺的合成和表征及其在硫代甲酰胺合成中的应用

摘要 实现了一种以纳米 TiO2 为催化剂合成 N 保护甲酰胺的有效方案。在催化量的纳米二氧化钛存在下用甲酸处理由 N-保护的酰基叠氮化物的 Curtius 重排形成的异氰酸酯，得到甲酰胺。此外，这些甲酰胺被用于合成具有生物活性的硫代甲酰胺。合成的N-保护甲酰胺和硫代甲酰胺通过IR、1H NMR、13C NMR和HRMS表征。靶分子受到体外抗菌和抗真菌活性的影响。采用水热法制备纳米TiO2，并通过XRD、FTIR、SEM、EDX和TEM技术进行了验证。