Lysozyme-secreting Paneth cells are abnormally present in the distal colons of patients with inflammatory bowel disease (IBD), along with high amounts of lysozyme in feces. In a recent article in Immunity, Yu et al. show that lysozyme-mediated processing of luminal bacteria in the colon triggers a proinflammatory response and predisposes mice to experimental IBD.

中文翻译：

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溶菌酶：肠道中的双刃剑

炎症性肠病（IBD）患者的远端结肠中异常分泌分泌溶菌酶的Paneth细胞，粪便中含有大量溶菌酶。在《免疫》杂志的最新文章中，Yu等人。表明溶菌酶介导的结肠内腔细菌的加工触发了促炎反应，并使小鼠易患实验性IBD。