Abstract In this research the experimental solubility of meloxicam (MLX) in {formamide (FM) + water}, {N-methylformamide (NMF) + water} and {N,N-dimethylformamide (DMF) + water} mixtures were determined at five temperatures, 293.15 K, 298.15 K, 303.15 K, 308.15 K and 313.15 K. MLX solubility increases with the cosolvent proportion in the mixtures and with temperature arising. Experimental solubility of MLX was modelled by using three well-known cosolvency models, namely the combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R-K), Modified-Wilson model and Jouyban-Acree model. The mean relative deviation (MPD%), in the accuracy of each mathematical model in relation to experimental solubility, shown CNIBS/R-K model is better in contrast to the other models. The model results were below of 3.21% for (FM + water) mixtures, to each temperature in the study. Furthermore, these were below of 1.72% for (NMF + water) mixtures and below of 1.70% for (DMF + water) mixtures, respectively. Apparent thermodynamic quantities of dissolution and mixing, as well as the preferential solvation parameters of MLX were calculated. Gibbs energies and enthalpies of dissolution were positive whereas the respective entropies were negative. MLX is preferentially solvated by water molecules in water-rich mixtures but preferentially solvated by cosolvent molecules in mixtures of cosolvent-rich mixtures.

中文翻译：

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美洛昔康在甲酰胺、N-甲基甲酰胺和 N,N-二甲基甲酰胺的含水二元混合物中的溶解度：测定、相关性、热力学和优先溶剂化

摘要 在本研究中，美洛昔康 (MLX) 在 {甲酰胺 (FM) + 水}、{N-甲基甲酰胺 (NMF) + 水} 和 {N,N-二甲基甲酰胺 (DMF) + 水} 混合物中的实验溶解度在 5温度、293.15 K、298.15 K、303.15 K、308.15 K 和 313.15 K。MLX 溶解度随着混合物中助溶剂比例和温度升高而增加。MLX 的实验溶解度是通过使用三个众所周知的共溶性模型来建模的，即组合近乎理想的二元溶剂/Redlich-Kister (CNIBS/RK)、Modified-Wilson 模型和 Jouyban-Acree 模型。平均相对偏差 (MPD%)，在与实验溶解度相关的每个数学模型的准确性中，显示 CNIBS/RK 模型与其他模型相比更好。对于（FM + 水）混合物，模型结果低于 3.21%，研究中的每个温度。此外，对于（NMF + 水）混合物，这些分别低于 1.72% 和对于（DMF + 水）混合物低于 1.70%。计算了溶解和混合的表观热力学量，以及 MLX 的优先溶剂化参数。吉布斯能量和溶解焓为正，而各自的熵为负。MLX 在富水混合物中优先被水分子溶剂化，但在富助溶剂混合物的混合物中优先被助溶剂分子溶剂化。吉布斯能量和溶解焓为正，而各自的熵为负。MLX 在富水混合物中优先被水分子溶剂化，但在富助溶剂混合物的混合物中优先被助溶剂分子溶剂化。吉布斯能量和溶解焓为正，而各自的熵为负。MLX 在富水混合物中优先被水分子溶剂化，但在富助溶剂混合物的混合物中优先被助溶剂分子溶剂化。