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Insights from nanotechnology in COVID-19 treatment
Nano Today ( IF 13.2 ) Pub Date : 2020-11-04 , DOI: 10.1016/j.nantod.2020.101019
Zhongmin Tang 1, 2 , Xingcai Zhang 3, 4 , Yiqing Shu 1 , Ming Guo 3 , Han Zhang 1 , Wei Tao 2
Affiliation  

In just a few months, SARS-CoV-2 and the disease it causes, COVID-19, created a worldwide pandemic. Virologists, biologists, pharmacists, materials scientists, and clinicians are collaborating to develop efficient treatment strategies. Overall, in addition to the use of clinical equipment to assist patient rehabilitation, antiviral drugs and vaccines are the areas of greatest focus. Given the physical size of SARS-CoV-2 and the vaccine delivery platforms currently in clinical trials, the relevance of nanotechnology is clear, and previous antiviral research using nanomaterials also supports this connection. Herein we briefly summarize current representative strategies regarding nanomaterials in antiviral research. We focus specifically on SARS-CoV-2 and the detailed role that nanotechnology can play in addressing this pandemic, including i) using FDA-approved nanomaterials for drug/vaccine delivery, including further exploration of the inhalation pathway; ii) introducing promising nanomaterials currently in clinical trials for drug/vaccine delivery; iii) designing novel biocompatible nanomaterials to combat the virus via interfering in its life cycle; and iv) promoting the utilization of nanomaterials in pneumonia treatment.

中文翻译:

纳米技术在 COVID-19 治疗中的见解

在短短几个月内,SARS-CoV-2 及其引起的疾病 COVID-19 引发了全球大流行。病毒学家、生物学家、药剂师、材料科学家和临床医生正在合作开发有效的治疗策略。总体而言,除了利用临床设备辅助患者康复外,抗病毒药物和疫苗是最受关注的领域。鉴于 SARS-CoV-2 的物理尺寸和目前正在进行临床试验的疫苗递送平台,纳米技术的相关性是显而易见的,之前使用纳米材料的抗病毒研究也支持这种联系。在此,我们简要总结了当前纳米材料在抗病毒研究中的代表性策略。我们特别关注 SARS-CoV-2 以及纳米技术在应对这一流行病中可以发挥的详细作用,包括 i) 使用 FDA 批准的纳米材料进行药物/疫苗输送,包括进一步探索吸入途径; ii) 引入目前正在临床试验中用于药物/疫苗输送的有前景的纳米材料; iii) 设计新型生物相容性纳米材料,通过干扰病毒的生命周期来对抗病毒; iv) 促进纳米材料在肺炎治疗中的应用。
更新日期:2020-11-04
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