Covalent organic frameworks (COFs) are functional porous crystalline “molecular Legos” entirely composed of light elements and held together by covalent bonds. Their synthesis typically relies on the formation of reversible covalent bonds linking multivalent monomers. While the reversibility in linkage formation imparts error correction and defect healing that dictate crystallinity, the thermodynamic characteristics intrinsically limit the chemical stability of COFs and constrain their further applications. To overcome chemical stability issues, considerable research efforts have been devoted to developing robust COFs by strengthening covalent linkages, tailoring noncovalent interactions, and manipulating inherent properties of linkers. In this review, we first summarize the state-of-the-art development of chemically robust COFs, then scrutinize the intriguing applications of chemically robust COFs in heterogeneous catalysis, environmental remediation, chiral separation, corrosive gas sensing, and lithium-ion batteries. We further present the major challenges and opportunities in future research directions and perspectives of chemically robust COFs.

共价有机骨架（COF）是功能性多孔晶体“分子乐高积木”，完全由轻元素组成，并通过共价键结合在一起。它们的合成通常依赖于连接多价单体的可逆共价键的形成。尽管键形成中的可逆性赋予了决定结晶度的错误校正和缺陷修复能力，但热力学特性从本质上限制了COF的化学稳定性并限制了它们的进一步应用。为了克服化学稳定性问题，已经通过加强共价键，定制非共价相互作用和操纵接头的固有性质，致力于开发鲁棒的COF，这是相当大的研究努力。在这篇评论中，我们首先总结化学稳健的COF的最新发展，然后仔细研究化学稳健的COF在异相催化，环境修复，手性分离，腐蚀性气体感应和锂离子电池中的有趣应用。我们进一步提出了未来研究方向和化学稳健的COF的主要挑战和机遇。