The necroptotic cell death pathway has received significant attention for its ability to trigger inflammatory responses and its potential involvement in related conditions. Recent insights into the essential membrane damaging necroptotic pseudokinase effector, Mixed lineage kinase domain like (MLKL), have revealed a growing number of diverse MLKL functions that contribute to the inflammatory nature of necroptosis. Here we review distinct MLKL signalling roles and document the immunogenic molecules released by necroptosis. We discuss specific in vivo MLKL-driven responses, the activation of inflammasome complexes and innate lymphoid cells that have been documented to drive disease. Finally, we list necroptotic competent cell types and their involvement in MLKL-driven cell death-associated and inflammatory-associated conditions.

坏死性细胞死亡途径因其触发炎症反应的能力及其在相关疾病中的潜在参与而受到了极大的关注。最近对基本膜损伤性坏死性假激酶效应物，混合谱系激酶结构域 (MLK​​L) 的见解揭示了越来越多的不同 MLKL 功能，这些功能有助于坏死性凋亡的炎症性质。在这里，我们回顾了不同的 MLKL 信号传导作用并记录了坏死性凋亡释放的免疫原性分子。我们讨论具体的体内MLKL 驱动的反应，炎症小体复合物和先天淋巴细胞的激活已被记录为驱动疾病。最后，我们列出了坏死性感受态细胞类型及其参与 MLKL 驱动的细胞死亡相关和炎症相关病症。