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MOF-shielded and glucose-responsive ultrasmall silver nano-factory for highly-efficient anticancer and antibacterial therapy
Chemical Engineering Journal ( IF 13.3 ) Pub Date : 2020-11-04 , DOI: 10.1016/j.cej.2020.127610
Yaojia Li , Zhiguo Gao , Yu Zhang , Fanghui Chen , Peijing An , Hongshuai Wu , Chaoqun You , Baiwang Sun

Ag nanoparticles, a widely used antimicrobial agent, have been recently found to show unexpected anticancer effects. However, its medical applications in anticancer and antibacterial field are significantly hindered due to the size-dependent bioactivity. Considering the close relationship between tumor incidence and infection, herein, we reported the controlled encapsulation of large-size single Ag nanocube (50 nm) in zeolitic imidazolate frameworks (ZIF), accompanied with embedding of glucose oxidase (GOD). The obtained GOD/Ag@ZIF could act as Ag nano-factory to generate ultrasmall Ag NPs (5 nm) as a response to tumor microenvironment. Specifically, GOD-induced generated H2O2 in glycolysis continuously decomposed AgNC into Ag+ and ultrasmall Ag NPs, where biocompatible ZIF-8 acted as the porous support for Ag+ and Ag NPs formation. Further, the GOD/Ag@ZIF were coated with hyaluronic acid (HA), termed by GOD/Ag@ZIF-HA, to allow the nanocomposites with good biocompatibility and target ability. GOD/Ag@ZIF-HA could completely suppress growth of two model bacteria strains at low concentration (E. coli. for 5 μg/mL, S. aureus for 10 μg/mL). More importantly, the high-performance anticancer activity of GOD/Ag@ZIF-HA and the underlying mechanism was also elaborated based on MCF-7 breast tumor model. We believe this study presents enticing possibilities to break through the size restriction of Ag NPs in biomedicine application.



中文翻译:

具有MOF屏蔽和葡萄糖响应的超小型银纳米工厂,可进行高效的抗癌和抗菌治疗

最近发现,广泛使用的抗菌剂Ag纳米粒子显示出出乎意料的抗癌作用。然而,由于其大小依赖性的生物活性,其在抗癌和抗菌领域的医学应用受到了极大的阻碍。考虑到肿瘤发生率和感染之间的密切关系,在本文中,我们报道了在沸石咪唑酸盐骨架(ZIF)中大型单Ag纳米立方体(50 nm)的受控包封,并嵌入了葡萄糖氧化酶(GOD)。获得的GOD / Ag @ ZIF可以作为Ag纳米工厂,以产生超小的Ag NPs(5 nm)作为对肿瘤微环境的响应。具体而言,在糖酵解中,GOD诱导生成的H 2 O 2连续地将AgNC分解为Ag +和超小型Ag NP,其中生物相容性ZIF-8充当Ag +和Ag NP形成的多孔载体。此外,用透明质酸(HA)(称为GOD / Ag @ ZIF-HA)涂覆GOD / Ag @ ZIF,以使纳米复合材料具有良好的生物相容性和靶向能力。GOD / Ag @ ZIF-HA可以完全抑制两种模型细菌菌株在低浓度下的生长(大肠杆菌为5μg/ mL,金黄色葡萄球菌为10μg/ mL)。更重要的是,还基于MCF-7乳腺肿瘤模型详细阐述了GOD / Ag @ ZIF-HA的高性能抗癌活性及其潜在机制。我们相信这项研究提供了诱人的可能性,可以突破生物医学应用中Ag NPs的尺寸限制。

更新日期:2020-11-04
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