Biodegradable metals have great attraction to become orthopaedic implants. Here, we demonstrated a biodegradable magnesium alloy incorporated with essential element sodium through Sn-Na master alloying technique. The designed MgSnZnNa alloy presented better hardness and corrosion resistance due to the uniform distribution of Na in Mg₂Sn second phase and solid soluble Zn in Mg matrix. The co-release of Mg and Na ions resulted in advanced upregulation of osterix and osteocalcin expression in adipose derived stem cells in vitro. It significantly promoted the rat calvarial defect bone regeneration through osteogenesis and angiogenesis, attributed to the co-release of Na and Mg ions, by increasing the expression of calcitonin gene-related peptide, osteocalcin as well as vascular endothelial growth factor. The current study provided an innovative approach by using master alloy to incorporate essential elements (such as Na or K) for fabricating biodegradable Mg alloys with reduced galvanic corrosion and enhanced biological functions.

可生物降解的金属具有成为骨科植入物的巨大吸引力。在这里，我们展示了通过Sn-Na中间合金化技术与必需元素钠结合的可生物降解镁合金。由于Na在Mg ₂ Sn第二相中的均匀分布和固溶态Zn在Mg基体中的均匀分布，设计的MgSnZnNa合金具有更好的硬度和耐腐蚀性。Mg和Na离子的共同释放导致脂肪干细胞体外osterix和骨钙素表达的上调。它通过增加降钙素基因相关肽，骨钙素以及血管内皮生长因子的表达，通过成骨和血管生成显着促进了大鼠颅骨缺损骨再生，这归因于Na和Mg离子的共释放。当前的研究提供了一种创新的方法，通过使用中间合金结合基本元素（例如Na或K）来制造可生物降解的Mg合金，从而减少电偶腐蚀并增强生物功能。