There is an ongoing shift in demographics such that older persons will outnumber young persons in the coming years, and with it age-associated tissue attrition and increased diseases and disorders. There has been increased information on the association of the aging process with dysregulation of hematopoietic stem (HSC) and progenitor (HPC) cells, and hematopoiesis. This review provides an extensive up-to date summary on the literature of aged hematopoiesis and HSCs placed in context of potential artifacts of the collection and processing procedure, that may not be totally representative of the status of HSCs in their in vivo bone marrow microenvironment, and what the implications of this are for understanding aged hematopoiesis. This review covers a number of interactive areas, many of which have not been adequately explored. There are still many unknowns and mechanistic insights to be elucidated to better understand effects of aging on the hematopoietic system, efforts that will take multidisciplinary approaches, and that could lead to means to ameliorate at least some of the dysregulation of HSCs and HPCs associated with the aging process.

人口统计正在发生变化，未来几年老年人的数量将超过年轻人，随之而来的是与年龄相关的组织消耗以及疾病和病症的增加。关于衰老过程与造血干细胞 (HSC) 和祖细胞 (HPC) 以及造血功能失调之间的关系的信息越来越多。本综述提供了关于老年造血和 HSC 的文献的广泛最新总结，这些文献置于收集和处理程序的潜在伪影的背景下，这可能不能完全代表 HSC 在体内骨髓微环境中的状态，以及这对于理解老年造血作用有何影响。这篇评论涵盖了许多互动领域，其中许多领域尚未得到充分探讨。为了更好地理解衰老对造血系统的影响，仍有许多未知因素和机制有待阐明，需要采取多学科方法，这可能会找到改善至少部分与造血系统相关的 HSC 和 HPC 失调的方法。老化过程。