Non-motor symptoms (NMS) occur in patients with cervical dystonia (CD) but with variable frequencies and impact on health-related quality of life (HRQoL). To define non-motor and motor profiles and their respective impact on HRQoL in CD patients using the newly validated Dystonia Non-Motor Symptoms Questionnaire (DNMSQuest). In an observational prospective multicentre case–control study, we enrolled 61 patients with CD and 61 age- and sex-matched healthy controls (HC) comparing demographic data, motor and non-motor symptoms and HRQoL measurements. 95% CD patients reported at least one NMS. Mean total NMS score was significantly higher in CD patients (5.62 ± 3.33) than in HC (1.74 ± 1.52; p < 0.001). Pain, insomnia and stigma were the most prevalent NMS and HRQoL was significantly impaired in CD patients compared to HC. There was strong correlation of NMS burden with HRQoL (CDQ-24: r = 0.72, EQ-5D: r = − 0.59; p < 0.001) in CD patients. Regression analysis between HRQoL and NMS suggested that emotional well-being (standardized beta = − 0.352) and pain (standardized beta = − 0.291) had a major impact on HRQoL while, in contrast motor severity had no significant impact in this model. Most NMS with the exception of pain, stigma and ADL did not correlate with motor severity. NMS are highly prevalent in CD patients and occur independent of age, sex, disease duration, duration of botulinum neurotoxin therapy and socio-economic status. Specific NMS such as emotional well-being and pain have a major impact on HRQoL and are more relevant than motor severity.

非运动症状 (NMS) 发生在颈肌张力障碍 (CD) 患者中，但频率不同，并且对健康相关生活质量 (HRQoL) 有影响。使用新验证的肌张力障碍非运动症状问卷 (DNMSQuest) 定义非运动和运动特征及其各自对 CD 患者 HRQoL 的影响。在一项观察性前瞻性多中心病例对照研究中，我们招募了 61 名 CD 患者和 61 名年龄和性别匹配的健康对照 (HC)，比较了人口统计数据、运动和非运动症状以及 HRQoL 测量值。95% 的 CD 患者报告了至少一种 NMS。CD 患者的平均 NMS 总分 (5.62 ± 3.33) 显着高于 HC (1.74 ± 1.52; p < 0.001)。疼痛、失眠和耻辱是最普遍的 NMS，与 HC 相比，CD 患者的 HRQoL 显着受损。NMS 负担与 HRQoL 有很强的相关性（CDQ-24：r  = 0.72，EQ-5D：r  = - 0.59；p < 0.001) 在 CD 患者中。HRQoL 和 NMS 之间的回归分析表明，情绪健康（标准化 beta = - 0.352）和疼痛（标准化 beta = - 0.291）对 HRQoL 有重大影响，而相比之下，运动严重程度在该模型中没有显着影响。除疼痛、耻辱感和 ADL 外，大多数 NMS 与运动严重程度无关。NMS 在 CD 患者中非常普遍，并且与年龄、性别、疾病持续时间、肉毒杆菌神经毒素治疗的持续时间和社会经济地位无关。特定的 NMS（例如情绪健康和疼痛）对 HRQoL 有重大影响，并且比运动严重程度更相关。