Abstract

Photodynamic therapy is a light-activated medical technique, which has received increasing attention within the last decade to treat various diseases including bacterial, viral or fungal infections as well as cancer. To overcome the limitations of the currently clinically applied photosensitizers based on a tetrapyrrolic scaffold, metal complexes are sought to be an interesting alternative. While these complexes show attractive photophysical and biological properties, the majority of these compounds are excited using visible light, which is associated with a poor tissue penetration. To circumvent this drawback, increasing attention has been devoted towards the use of 2-Photon instead of 1-Photon irradiation. In this mini-review, the metal complexes prepared in view of 2P-PDT are reviewed and the requirements these compounds need to fulfil to be of interest are critically discussed.

Graphic abstract

中文翻译：

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批判性讨论金属配合物在2光子光动力疗法中的应用

摘要

光动力疗法是一种光激活的医学技术，在过去的十年中，它已受到越来越多的关注，用于治疗包括细菌，病毒或真菌感染以及癌症在内的各种疾病。为了克服目前基于四吡咯支架的临床上应用的光敏剂的局限性，寻求金属络合物作为一种有趣的选择。虽然这些复合物显示出有吸引力的光物理和生物学特性，但这些化合物中的大多数是使用可见光激发的，这与不良的组织穿透性有关。为了克服该缺点，已经越来越关注使用2-光子代替1-光子辐照。在此迷你评论中，

图形摘要