The Hippo signal transduction pathway is an essential regulator of organ size during developmental growth by controlling multiple cellular processes such as cell proliferation, cell death, differentiation, and stemness. Dysfunctional Hippo signaling pathway leads to dramatic tissue overgrowth. Here, we will briefly introduce the Hippo tumor suppressor pathway before focusing on one of its members and the unexpected twists that followed our quest of its functions in its multifarious actions beside the Hippo pathway: the STK38 kinase. In this review, we will precisely discuss the newly identified role of STK38 on regulating the nuclear export machinery by phosphorylating and activating, the major nuclear export receptor XPO1. Finally, we will phrase STK38′s role on regulating the subcellular distribution of crucial cellular regulators such as Beclin1 and YAP1 with its implication in cancer.

通过控制多种细胞过程，例如细胞增殖，细胞死亡，分化和干性，河马信号转导途径是发育生长期间器官大小的重要调节剂。功能失调的河马信号通路导致组织过度生长。在这里，我们将简要介绍Hippo抑癌途径，然后重点介绍其成员之一以及在我们寻求其在Hippo途径旁边的多种作用中的功能后出现的意外转折：STK38激酶。在这篇综述中，我们将精确地讨论STK38通过磷酸化和激活主要的核出口受体XPO1调节核出口机械的新发现的作用。最后，