A novel electrochemical sensor was constructed for the determination of artemisinin (ART) based on the inhibition of redox for hemin caused by ART. As far as we know, this strategy for ART determination may be proposed for the first time. In this work, untreated multi-walled carbon nanotubes were cast on the glassy carbon electrode (GCE) as conductive carrier. We prepared a bimetallic organic framework named FeGd-MOF and combined it with hemin by a simple physical mixed method. Then, we fabricated the working electrode by layer-by-layer modification and immobilization. The sensor measured by the differential pulse voltammetry (DPV) technique had calibration curves for the determination of ART, which was 0.3–350 μM with the correlation coefficient R² = 0.9998. Furthermore, the obtained linear range could be practically used in real sample analysis such as dried leaves of Artemisia apiacea. Under the optimized condition, the electrochemical sensor exhibited high sensitivity, good stability, and excellent anti-interference performance. The limit of detection (LOD) for this sensor was 0.17 μM (signal to noise ratio, S/N = 3), which was much lower than that for some other reported electrochemical sensors. The recovery rates were in the range of 99.54–104.34% in real samples, indicating that the sensor had good repetition and high accuracy.

基于ART引起的血红素氧化还原的抑制，构建了一种用于测定青蒿素（ART）的新型电化学传感器。据我们所知，这种ART确定策略可能是第一次提出。在这项工作中，将未经处理的多壁碳纳米管浇铸在作为导电载体的玻碳电极（GCE）上。我们制备了一种名为 FeGd-MOF 的双金属有机骨架，并通过简单的物理混合方法将其与氯化血红素结合。然后，我们通过逐层修饰和固定来制造工作电极。通过差分脉冲伏安法 (DPV) 技术测量的传感器具有用于测定 ART 的校准曲线，为 0.3–350 μM，相关系数为R ² = 0.9998。此外，获得的线性范围可以实际用于实际样品分析，例如青蒿的干叶。在优化条件下，电化学传感器表现出高灵敏度、良好的稳定性和优异的抗干扰性能。该传感器的检测限 (LOD) 为 0.17 μM（信噪比，S / N  = 3），远低于其他一些报道的电化学传感器。实际样品的回收率在99.54-104.34%之间，表明该传感器具有良好的重复性和高精度。