The Nuclear receptor 4A (NR4A) subfamily, which belongs to the nuclear receptor (NR) superfamily, has three members: NR4A1 (Nur77), NR4A2 (Nurr1) and NR4A3 (Nor1). They are gene regulators with broad involvement in various signaling pathways and human disease responses, including autophagy. Here, we provide a concise overview of the current understanding of the role of the NR4A subfamily members in human diseases and review the research into their regulation of cell autophagy. A deeper understanding of these mechanisms has potential to improve drug development processes and disease therapy.

中文翻译：

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核受体 4A 家族成员：人类疾病和自噬的介质


核受体4A（NR4A）亚家族属于核受体（NR）超家族，共有三个成员：NR4A1（Nur77）、NR4A2（Nurr1）和NR4A3（Nor1）。它们是基因调节因子，广泛参与各种信号通路和人类疾病反应，包括自噬。在此，我们简要概述了目前对 NR4A 亚家族成员在人类疾病中的作用的认识，并回顾了其调节细胞自噬的研究。对这些机制的更深入了解有可能改善药物开发过程和疾病治疗。