当前位置: X-MOL 学术EJNMMI Phys. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Performance evaluation of fifth-generation ultra-high-resolution SPECT system with two stationary detectors and multi-pinhole imaging
EJNMMI Physics ( IF 3.0 ) Pub Date : 2020-11-02 , DOI: 10.1186/s40658-020-00335-6
Jan V. Hoffmann , Jan P. Janssen , Takayuki Kanno , Takayuki Shibutani , Masahisa Onoguchi , Constantin Lapa , Jan-Peter Grunz , Andreas K. Buck , Takahiro Higuchi

Small-animal single-photon emission computed tomography (SPECT) systems with multi-pinhole collimation and large stationary detectors have advantages compared to systems with moving small detectors. These systems benefit from less labour-intensive maintenance and quality control as fewer prone parts are moving, higher accuracy for focused scans and maintaining high resolution with increased sensitivity due to focused pinholes on the field of view. This study aims to investigate the performance of a novel ultra-high-resolution scanner with two-detector configuration (U-SPECT5-E) and to compare its image quality to a conventional micro-SPECT system with three stationary detectors (U-SPECT+). The new U-SPECT5-E with two stationary detectors was used for acquiring data with 99mTc-filled point source, hot-rod and uniformity phantoms to analyse sensitivity, spatial resolution, uniformity and contrast-to-noise ratio (CNR). Three dedicated multi-pinhole mouse collimators with 75 pinholes each and 0.25-, 0.60- and 1.00-mm pinholes for extra ultra-high resolution (XUHR-M), general-purpose (GP-M) and ultra-high sensitivity (UHS-M) imaging were examined. For CNR analysis, four different activity ranges representing low- and high-count settings were investigated for all three collimators. The experiments for the performance assessment were repeated with the same GP-M collimator in the three-detector U-SPECT+ for comparison. Peak sensitivity was 237 cps/MBq (XUHR-M), 847 cps/MBq (GP-M), 2054 cps/MBq (UHS-M) for U-SPECT5-E and 1710 cps/MBq (GP-M) for U-SPECT+. In the visually analysed sections of the reconstructed mini Derenzo phantoms, rods as small as 0.35 mm (XUHR-M), 0.50 mm (GP-M) for the two-detector as well as the three-detector SPECT and 0.75 mm (UHS-M) were resolved. Uniformity for maximum resolution recorded 40.7% (XUHR-M), 29.1% (GP-M, U-SPECT5-E), 16.3% (GP-M, U-SPECT+) and 23.0% (UHS-M), respectively. UHS-M reached highest CNR values for low-count images; for rods smaller than 0.45 mm, acceptable CNR was only achieved by XUHR-M. GP-M was superior for imaging rods sized from 0.60 to 1.50 mm for intermediate activity concentrations. U-SPECT5-E and U-SPECT+ both provided comparable CNR. While uniformity and sensitivity are negatively affected by the absence of a third detector, the investigated U-SPECT5-E system with two stationary detectors delivers excellent spatial resolution and CNR comparable to the performance of an established three-detector-setup.

中文翻译:

具有两个固定探测器和多针孔成像的第五代超高分辨率SPECT系统的性能评估

与具有移动小探测器的系统相比,具有多针孔准直和大型固定探测器的小动物单光子发射计算机断层扫描(SPECT)系统具有优势。这些系统受益于更少的劳动密集型维护和质量控制,因为移动的俯卧零件更少,聚焦扫描的精度更高,并且由于视野上的针孔集中而保持了高分辨率和更高的灵敏度。这项研究旨在调查具有两个探测器配置(U-SPECT5-E)的新型超高分辨率扫描仪的性能,并将其图像质量与具有三个固定探测器(U-SPECT +)的常规micro-SPECT系统进行比较。带有两个固定探测器的新型U-SPECT5-E用于采集充满99mTc点源的数据,热棒和均匀度模型,以分析灵敏度,空间分辨率,均匀度和对比度和噪声比(CNR)。三个专用的多针孔鼠标准直仪,每个都有75个针孔,以及0.25、0.60和1.00mm针孔,可提供超高分辨率(XUHR-M),通用(GP-M)和超高灵敏度(UHS- M)检查成像。对于CNR分析,对所有三个准直仪研究了代表低计数值设置和高计数值设置的四个不同的活动范围。在三探测器U-SPECT +中使用相同的GP-M准直仪重复进行性能评估实验,以进行比较。U-SPECT5-E的峰值灵敏度为237 cps / MBq(XUHR-M),847 cps / MBq(GP-M),U-SPECT5-E为2054 cps / MBq(UHS-M),U的峰值灵敏度为1710 cps / MBq(GP-M) -SPECT +。在重建的迷你Derenzo体模的视觉分析部分中,解决了两个探测器以及三个探测器SPECT的小至0.35 mm(XUHR-M),0.50 mm(GP-M)的杆和0.75 mm(UHS-M)的问题。最大分辨率的均匀度分别为40.7%(XUHR-M),29.1%(GP-M,U-SPECT5-E),16.3%(GP-M,U-SPECT +)和23.0%(UHS-M)。对于低计数图像,UHS-M达到了最高CNR值;对于小于0.45 mm的棒,只有通过XUHR-M才能获得可接受的CNR。对于中等活性浓度,GP-M对于成像棒的尺寸范围从0.60到1.50 mm更好。U-SPECT5-E和U-SPECT +均提供了可比的CNR。尽管缺少第三个检测器会对均匀性和灵敏度产生负面影响,但研究的带有两个固定检测器的U-SPECT5-E系统具有出色的空间分辨率和CNR,可与已建立的三个检测器设置媲美。解决了两个探测器以及三个探测器SPECT的35 mm(XUHR-M),0.50 mm(GP-M)和0.75 mm(UHS-M)的问题。最大分辨率的均匀度分别为40.7%(XUHR-M),29.1%(GP-M,U-SPECT5-E),16.3%(GP-M,U-SPECT +)和23.0%(UHS-M)。对于低计数图像,UHS-M达到了最高CNR值;对于小于0.45 mm的棒,只有通过XUHR-M才能获得可接受的CNR。对于中等活性浓度,GP-M对于成像棒的尺寸范围从0.60到1.50 mm更好。U-SPECT5-E和U-SPECT +均提供了可比的CNR。尽管缺少第三个检测器会对均匀性和灵敏度产生负面影响,但研究的带有两个固定检测器的U-SPECT5-E系统具有出色的空间分辨率和CNR,可与已建立的三个检测器设置媲美。解决了两个探测器以及三个探测器SPECT的35 mm(XUHR-M),0.50 mm(GP-M)和0.75 mm(UHS-M)的问题。最大分辨率的均匀度分别为40.7%(XUHR-M),29.1%(GP-M,U-SPECT5-E),16.3%(GP-M,U-SPECT +)和23.0%(UHS-M)。对于低计数图像,UHS-M达到了最高CNR值;对于小于0.45 mm的棒,只有通过XUHR-M才能获得可接受的CNR。对于中等活性浓度,GP-M对于成像棒的尺寸范围从0.60到1.50 mm更好。U-SPECT5-E和U-SPECT +均提供了可比的CNR。尽管缺少第三个检测器会对均匀性和灵敏度产生负面影响,但研究的带有两个固定检测器的U-SPECT5-E系统具有出色的空间分辨率和CNR,可与已建立的三个检测器设置媲美。解决了两个探测器以及三个探测器SPECT的50 mm(GP-M)和0.75 mm(UHS-M)的问题。最大分辨率的均匀度分别为40.7%(XUHR-M),29.1%(GP-M,U-SPECT5-E),16.3%(GP-M,U-SPECT +)和23.0%(UHS-M)。对于低计数图像,UHS-M达到了最高CNR值;对于小于0.45 mm的棒,只有通过XUHR-M才能获得可接受的CNR。对于中等活性浓度,GP-M对于成像棒的尺寸范围从0.60到1.50 mm更好。U-SPECT5-E和U-SPECT +均提供了可比的CNR。尽管缺少第三个检测器会对均匀性和灵敏度产生负面影响,但研究的带有两个固定检测器的U-SPECT5-E系统具有出色的空间分辨率和CNR,可与已建立的三个检测器设置媲美。解决了两个探测器以及三个探测器SPECT的50 mm(GP-M)和0.75 mm(UHS-M)的问题。最大分辨率的均匀度分别为40.7%(XUHR-M),29.1%(GP-M,U-SPECT5-E),16.3%(GP-M,U-SPECT +)和23.0%(UHS-M)。对于低计数图像,UHS-M达到了最高CNR值;对于小于0.45 mm的棒,只有通过XUHR-M才能获得可接受的CNR。对于中等活性浓度,GP-M对于成像棒的尺寸范围从0.60到1.50 mm更好。U-SPECT5-E和U-SPECT +均提供了可比的CNR。尽管缺少第三个检测器会对均匀性和灵敏度产生负面影响,但研究的带有两个固定检测器的U-SPECT5-E系统具有出色的空间分辨率和CNR,可与已建立的三个检测器设置媲美。75毫米(UHS-M)已解决。最大分辨率的均匀度分别为40.7%(XUHR-M),29.1%(GP-M,U-SPECT5-E),16.3%(GP-M,U-SPECT +)和23.0%(UHS-M)。对于低计数图像,UHS-M达到了最高CNR值;对于小于0.45 mm的棒,只有通过XUHR-M才能获得可接受的CNR。对于中等活性浓度,GP-M对于成像棒的尺寸范围从0.60到1.50 mm更好。U-SPECT5-E和U-SPECT +均提供了可比的CNR。尽管缺少第三个检测器会对均匀性和灵敏度产生负面影响,但研究的带有两个固定检测器的U-SPECT5-E系统具有出色的空间分辨率和CNR,可与已建立的三个检测器设置媲美。75毫米(UHS-M)已解决。最大分辨率的均匀度分别为40.7%(XUHR-M),29.1%(GP-M,U-SPECT5-E),16.3%(GP-M,U-SPECT +)和23.0%(UHS-M)。对于低计数图像,UHS-M达到了最高CNR值;对于小于0.45 mm的棒,只有通过XUHR-M才能获得可接受的CNR。对于中等活性浓度,GP-M对于成像棒的尺寸范围从0.60到1.50 mm更好。U-SPECT5-E和U-SPECT +均提供了可比的CNR。尽管缺少第三个检测器会对均匀性和灵敏度产生负面影响,但研究的带有两个固定检测器的U-SPECT5-E系统具有出色的空间分辨率和CNR,可与已建立的三个检测器设置媲美。U-SPECT +)和23.0%(UHS-M)。对于低计数图像,UHS-M达到了最高CNR值;对于小于0.45 mm的棒,只有通过XUHR-M才能获得可接受的CNR。对于中等活性浓度,GP-M对于成像棒的尺寸范围从0.60到1.50 mm更好。U-SPECT5-E和U-SPECT +均提供了可比的CNR。尽管缺少第三个检测器会对均匀性和灵敏度产生负面影响,但研究的带有两个固定检测器的U-SPECT5-E系统具有出色的空间分辨率和CNR,可与已建立的三个检测器设置媲美。U-SPECT +)和23.0%(UHS-M)。对于低计数图像,UHS-M达到了最高CNR值;对于小于0.45 mm的棒,只有通过XUHR-M才能获得可接受的CNR。对于中等活性浓度,GP-M对于成像棒的尺寸范围从0.60到1.50 mm更好。U-SPECT5-E和U-SPECT +均提供了可比的CNR。尽管缺少第三个检测器会对均匀性和灵敏度产生负面影响,但研究的带有两个固定检测器的U-SPECT5-E系统具有出色的空间分辨率和CNR,可与已建立的三个检测器设置媲美。中间活动浓度为50毫米。U-SPECT5-E和U-SPECT +均提供了可比的CNR。尽管缺少第三个检测器会对均匀性和灵敏度产生负面影响,但研究的带有两个固定检测器的U-SPECT5-E系统具有出色的空间分辨率和CNR,可与已建立的三个检测器设置媲美。中间活动浓度为50毫米。U-SPECT5-E和U-SPECT +均提供了可比的CNR。尽管缺少第三个检测器会对均匀性和灵敏度产生负面影响,但研究的带有两个固定检测器的U-SPECT5-E系统具有出色的空间分辨率和CNR,可与已建立的三个检测器设置媲美。
更新日期:2020-11-03
down
wechat
bug