ATP-dependent chromatin remodeling by histone-modifying enzymes and chromatin remodeling complexes is crucial for maintaining chromatin organization and facilitating gene transcription. In the SWI/SNF family of ATP-dependent chromatin remodelers, distinct complexes such as BAF, PBAF, GBAF, esBAF and npBAF/nBAF are of particular interest regarding their implications in cellular differentiation and development, as well as in various diseases. The recently identified BAF subcomplex GBAF is no exception to this, and information is emerging linking this complex and its components to crucial events in mammalian development. Furthermore, given the essential nature of many of its subunits in maintaining effective chromatin remodeling function, it comes as no surprise that aberrant expression of GBAF complex components is associated with disease development, including neurodevelopmental disorders and numerous malignancies. It becomes clear that building upon our knowledge of GBAF and BAF complex function will be essential for advancements in both mammalian reproductive applications and the development of more effective therapeutic interventions and strategies. Here, we review the roles of the SWI/SNF chromatin remodeling subcomplex GBAF and its subunits in mammalian development and disease.

中文翻译：

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GBAF，一个具有重大意义的小型BAF子复合体：系统综述

组蛋白修饰酶和染色质重塑复合物对ATP的依赖性染色质重塑对于维持染色质组织和促进基因转录至关重要。在SWI / SNF家族的ATP依赖的染色质重塑剂中，不同的复合物（例如BAF，PBAF，GBAF，esBAF和npBAF / nBAF）对于它们在细胞分化和发育以及各种疾病中的意义特别感兴趣。最近发现的BAF亚复合物GBAF也不例外，并且正在出现将这种复合物及其成分与哺乳动物发育中的关键事件联系起来的信息。此外，鉴于其许多亚基在维持有效的染色质重塑功能中的本质，不足为奇的是，GBAF复杂成分的异常表达与疾病发展相关，包括神经发育障碍和许多恶性肿瘤。很显然，基于我们对GBAF和BAF的了解，复杂功能对于哺乳动物生殖应用的发展以及更有效的治疗干预措施和策略的发展必不可少。在这里，我们回顾了SWI / SNF染色质重塑亚复合体GBAF及其亚基在哺乳动物发育和疾病中的作用。很显然，基于我们对GBAF和BAF的了解，复杂功能对于哺乳动物生殖应用的发展以及更有效的治疗干预措施和策略的发展必不可少。在这里，我们回顾了SWI / SNF染色质重塑亚复合体GBAF及其亚基在哺乳动物发育和疾病中的作用。很显然，基于我们对GBAF和BAF的了解，复杂功能对于哺乳动物生殖应用的发展以及更有效的治疗干预措施和策略的发展必不可少。在这里，我们回顾了SWI / SNF染色质重塑亚复合体GBAF及其亚基在哺乳动物发育和疾病中的作用。