Extreme bone resorption due to bone remodelling is one of the reasons for ankle component loosening. Finite element (FE) analysis has been effectively used nowadays for pre-clinical analysis of orthopaedic implants. For FE modelling, the selection of bone material and dead zone play a vital role to understand the bone remodelling. This study deals with the effects of different cancellous elastic modulus-density relationships and dead zone on bone remodelling around the tibia owing to total ankle replacement (TAR), using finite element analysis with physiological loading conditions. This study also investigated the bone stimulus distribution in the tibia to identify the initial indication of bone density changes due to bone remodelling. Additionally, the Hoffman failure criterion was used to investigate the chances of implant-bone interface failure due to different cancellous bone material modelling and bone remodelling. The present bone remodelling study consists of three different dead or lazy zones (±0.75, ±0.60 and ±0.35) to examine the influence of the dead zone on bone remodelling. Differences in stress/strain distribution were observed in the tibia bone due to different cancellous bone material modelling. Despite little variations, bone density changes due to bone remodelling were found to be almost similar for two FE models having different cancellous bone material. Similar to these results, the effect of different dead zone on bone density changes due to bone remodelling was found to be minimal. Bone stimulus distribution in the cancellous bone was found to be almost similar for FE models having different cancellous bone material modelling and different dead zones. To understand the stress/strain and interface related failure of the tibial component, cancellous bone material modelling plays a crucial role. However, cancellous bone material modelling and dead zone have minimal influence on bone remodelling around the tibia cancellous bone due to TAR.

由于骨重塑导致的极端骨吸收是踝关节组件松动的原因之一。如今，有限元 (FE) 分析已被有效地用于骨科植入物的临床前分析。对于有限元建模，骨骼材料和死区的选择对于理解骨骼重塑起着至关重要的作用。本研究使用有限元分析和生理负荷条件，研究不同松质弹性模量-密度关系和死区对全踝关节置换术 (TAR) 引起的胫骨周围骨重塑的影响。该研究还调查了胫骨中的骨刺激分布，以确定由于骨重塑引起的骨密度变化的初始迹象。此外，霍夫曼失效准则用于研究由于不同的松质骨材料建模和骨重建而导致种植体-骨界面失效的几率。目前的骨重建研究包括三个不同的死区或惰性区（±0.75、±0.60 和 ±0.35），以检查死区对骨重建的影响。由于不同的松质骨材料建模，在胫骨中观察到应力/应变分布的差异。尽管几乎没有变化，但对于具有不同松质骨材料的两个 FE 模型，发现由于骨重塑引起的骨密度变化几乎相似。与这些结果类似，发现不同死区对骨重建引起的骨密度变化的影响最小。对于具有不同松质骨材料模型和不同死区的 FE 模型，发现松质骨中的骨刺激分布几乎相似。为了了解胫骨组件的应力/应变和界面相关失效，松质骨材料建模起着至关重要的作用。然而，由于 TAR，松质骨材料建模和死区对胫骨松质骨周围的骨重塑影响很小。