The recent scientific progress has shown the promising effect of the vaccine in immunotherapy of cancer, which relies on the antigen processing/presentation capability of dendritic cells (DCs). As a result, cancer vaccines targeting DC, which also named as DC vaccine, was a hot-spot in vaccine development. Herein, a nanostructured lipid carrier (NLC) was employed to load chlorin e6 (Ce6) to serve as a potential in situ DC vaccine (NLC/Ce6) for effective immunotherapy of gastric cancer. Taking advantage of the photodynamic effect of Ce6 to generate reactive oxygen species (ROS) under laser irradiation, the NLC/Ce6 was able to trigger cell death and expose tumor-associated antigen (TAA). Moreover, mimicking the natural inflammatory response, the ROS can also recruit the DC for the effective processing/presentation of the in situ exposed TAA. As expected, we observed strong capability DC vaccination efficacy of this platform to effectively inhibit the growth of both primary and distant gastric tumors.

中文翻译：

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递送二氢卟酚 e6 的纳米结构脂质载体作为用于胃癌免疫治疗的原位树突细胞疫苗

最近的科学进展表明，该疫苗在癌症免疫治疗中具有良好的效果，这依赖于树突状细胞 (DC) 的抗原加工/呈递能力。因此，靶向DC的癌症疫苗，又称DC疫苗，成为疫苗研发的热点。在此，采用纳米结构脂质载体 (NLC) 负载二氢卟酚 e6 (Ce6) 作为潜在的原位 DC 疫苗 (NLC/Ce6)，用于胃癌的有效免疫治疗。利用 Ce6 的光动力效应在激光照射下产生活性氧 (ROS)，NLC/Ce6 能够触发细胞死亡并暴露肿瘤相关抗原 (TAA)。此外，模拟自然炎症反应，ROS 还可以招募 DC 以有效处理/呈现原位暴露的 TAA。