Interest in anti-inflammatory IRAK4 signaling is ramping up, as small-molecule ‘degraders’ that bind both the kinase and E3 ubiquitin ligases prepare to take on traditional kinase inhibitors.

中文翻译：

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IRAK4降解剂具有先天免疫力

随着结合激酶和E3泛素连接酶的小分子“降解剂”准备采用传统的激酶抑制剂，人们对抗炎IRAK4信号的兴趣正在增加。