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Assessment of the relationship between endocan and obstructive sleep apnea severity
Archives of Medical Science ( IF 3.0 ) Pub Date : 2020-08-03 , DOI: 10.5114/aoms.2020.97764 Hamdi Pusuroglu 1 , Umut Somuncu 1 , Ismail Bolat 2 , Ozgur Akgul 1 , Hayriye Ak Yıldırım 3 , Sinem Ozbay Ozyilmaz 1 , Vesile Ornek 3 , Ozgur Surgit 1 , Huseyin Karakurt 1 , Ayfer Utkusavas 4 , Nermina Alagic 1 , Aydın Yıldırım 1
Archives of Medical Science ( IF 3.0 ) Pub Date : 2020-08-03 , DOI: 10.5114/aoms.2020.97764 Hamdi Pusuroglu 1 , Umut Somuncu 1 , Ismail Bolat 2 , Ozgur Akgul 1 , Hayriye Ak Yıldırım 3 , Sinem Ozbay Ozyilmaz 1 , Vesile Ornek 3 , Ozgur Surgit 1 , Huseyin Karakurt 1 , Ayfer Utkusavas 4 , Nermina Alagic 1 , Aydın Yıldırım 1
Affiliation
Introduction
Obstructive sleep apnea (OSA) and endothelial dysfunction are associated with cardiovascular risk factors and the development of atherosclerosis. Endocan is a marker of endothelial dysfunction, while obstructive sleep apnea is one of the causes of endothelial dysfunction. In this study, we investigated the relationship between endocan and obstructive sleep apnea severity.
Material and methods
A total of 179 patients with snoring complaints were included. All patients underwent polysomnography, and based on the results, the participations were allocated to the control group (n = 39) or to the obstructive sleep apnea group n = 140). The OSA group was classified as having mild (apnea-hypopnea index (AHI) = 5–15; n = 43), moderate (AHI = 15–30; n = 42), or severe OSA (AHI > 30; n = 55). All participations had their endocan levels measured.
Results
Endocan levels in OSA patients were significantly higher than in the control group (11.8 (3.13–200) vs 3.13 (3.13–23) ng/ml, p < 0.001). Also, endocan levels were significantly higher in the severe OSA group than moderate and mild obstructive OSA (13.2 (3.13–200), 12.6 (3.13–200) and 8.44 (3.13–50.5) ng/ml, p = 0.015, respectively). Multiple logistic regression analysis showed that smoking, age and endocan levels were independent predictors of OSA severity (p = 0.024, p = 0.037, p = 0.004, respectively).
Conclusions
Endocan seems to be a potential risk stratification marker in this patient population.
中文翻译：
评估endocan与阻塞性睡眠呼吸暂停严重程度之间的关系
简介
阻塞性睡眠呼吸暂停 (OSA) 和内皮功能障碍与心血管危险因素和动脉粥样硬化的发展有关。Endocan是内皮功能障碍的标志物，而阻塞性睡眠呼吸暂停是内皮功能障碍的原因之一。在这项研究中，我们调查了 endocan 与阻塞性睡眠呼吸暂停严重程度之间的关系。
材料与方法
共纳入 179 名有打鼾症状的患者。所有患者均接受了多导睡眠监测，并根据结果将参与者分配到对照组（n = 39）或阻塞性睡眠呼吸暂停组（n = 140）。OSA 组分为轻度（呼吸暂停低通气指数 (AHI) = 5-15；n = 43）、中度（AHI = 15-30；n = 42）或重度 OSA（AHI > 30；n = 55） ）。所有参与的人都测量了他们的内皮坎水平。
结果
OSA 患者的 Endocan 水平显着高于对照组（11.8 (3.13-200) vs 3.13 (3.13-23) ng/ml，p < 0.001）。此外，重度 OSA 组的 endocan 水平显着高于中度和轻度阻塞性 OSA（分别为 13.2（3.13-200）、12.6（3.13-200）和 8.44（3.13-50.5）ng/ml，p = 0.015）。多元逻辑回归分析表明，吸烟、年龄和 endocan 水平是 OSA 严重程度的独立预测因子（分别为 p = 0.024、p = 0.037、p = 0.004）。
结论
Endocan 似乎是该患者群体的潜在风险分层标志物。
更新日期：2020-08-03
Obstructive sleep apnea (OSA) and endothelial dysfunction are associated with cardiovascular risk factors and the development of atherosclerosis. Endocan is a marker of endothelial dysfunction, while obstructive sleep apnea is one of the causes of endothelial dysfunction. In this study, we investigated the relationship between endocan and obstructive sleep apnea severity.
Material and methods
A total of 179 patients with snoring complaints were included. All patients underwent polysomnography, and based on the results, the participations were allocated to the control group (n = 39) or to the obstructive sleep apnea group n = 140). The OSA group was classified as having mild (apnea-hypopnea index (AHI) = 5–15; n = 43), moderate (AHI = 15–30; n = 42), or severe OSA (AHI > 30; n = 55). All participations had their endocan levels measured.
Results
Endocan levels in OSA patients were significantly higher than in the control group (11.8 (3.13–200) vs 3.13 (3.13–23) ng/ml, p < 0.001). Also, endocan levels were significantly higher in the severe OSA group than moderate and mild obstructive OSA (13.2 (3.13–200), 12.6 (3.13–200) and 8.44 (3.13–50.5) ng/ml, p = 0.015, respectively). Multiple logistic regression analysis showed that smoking, age and endocan levels were independent predictors of OSA severity (p = 0.024, p = 0.037, p = 0.004, respectively).
Conclusions
Endocan seems to be a potential risk stratification marker in this patient population.
中文翻译：
评估endocan与阻塞性睡眠呼吸暂停严重程度之间的关系
简介
阻塞性睡眠呼吸暂停 (OSA) 和内皮功能障碍与心血管危险因素和动脉粥样硬化的发展有关。Endocan是内皮功能障碍的标志物，而阻塞性睡眠呼吸暂停是内皮功能障碍的原因之一。在这项研究中，我们调查了 endocan 与阻塞性睡眠呼吸暂停严重程度之间的关系。
材料与方法
共纳入 179 名有打鼾症状的患者。所有患者均接受了多导睡眠监测，并根据结果将参与者分配到对照组（n = 39）或阻塞性睡眠呼吸暂停组（n = 140）。OSA 组分为轻度（呼吸暂停低通气指数 (AHI) = 5-15；n = 43）、中度（AHI = 15-30；n = 42）或重度 OSA（AHI > 30；n = 55） ）。所有参与的人都测量了他们的内皮坎水平。
结果
OSA 患者的 Endocan 水平显着高于对照组（11.8 (3.13-200) vs 3.13 (3.13-23) ng/ml，p < 0.001）。此外，重度 OSA 组的 endocan 水平显着高于中度和轻度阻塞性 OSA（分别为 13.2（3.13-200）、12.6（3.13-200）和 8.44（3.13-50.5）ng/ml，p = 0.015）。多元逻辑回归分析表明，吸烟、年龄和 endocan 水平是 OSA 严重程度的独立预测因子（分别为 p = 0.024、p = 0.037、p = 0.004）。
结论
Endocan 似乎是该患者群体的潜在风险分层标志物。
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