The most widely accepted theory for the development of preeclampsia is the “two-stage theory”. An imbalance between antiangiogenic and proangiogenic factors is considered the link between the two stages. Nowadays, an increasing amount of data is available on the use of measurements of serum concentrations of these factors in the prediction, diagnosis and management of preeclampsia. The most useful, modern biochemical test that may help in making crucial clinical decisions in patients with preeclampsia is the sFlt-1/PlGF (soluble fms-like tyrosine kinase 1/placental growth factor) ratio. The aim of this review is to present the current use of different biochemical tests in the prediction, diagnosis and management of preeclampsia. Development of these diagnostic methods in recent years and a belief in their ground-breaking role in modern management of preeclampsia make this review especially important.

中文翻译：

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生化测试在先兆子痫的预测、诊断和临床管理中的效用：综述


对于先兆子痫的发展最广泛接受的理论是“两阶段理论”。抗血管生成因子和促血管生成因子之间的不平衡被认为是两个阶段之间的联系。如今，越来越多的数据表明，这些因子的血清浓度测量用于先兆子痫的预测、诊断和治疗。最有用的现代生化测试可能有助于对先兆子痫患者做出关键的临床决策，即 sFlt-1/PlGF（可溶性 fms 样酪氨酸激酶 1/胎盘生长因子）比率。本综述的目的是介绍目前不同生化测试在子痫前期的预测、诊断和治疗中的应用。近年来这些诊断方法的发展以及对其在先兆子痫现代治疗中的突破性作用的信念使得本次综述显得尤为重要。